Phosphorus in PDB 1aio: Crystal Structure of A Double-Stranded Dna Containing the Major Adduct of the Anticancer Drug Cisplatin

Protein crystallography data

The structure of Crystal Structure of A Double-Stranded Dna Containing the Major Adduct of the Anticancer Drug Cisplatin, PDB code: 1aio was solved by P.M.Takahara, A.C.Rosenzweig, C.A.Frederick, S.J.Lippard, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 8.00 / 2.60
Space group P 1
Cell size a, b, c (Å), α, β, γ (°) 31.270, 35.460, 47.010, 79.81, 84.75, 82.79
R / Rfree (%) 20.6 / 25.1

Phosphorus Binding Sites:

Pages:

>>> Page 1 <<< Page 2, Binding sites: 11 - 20; Page 3, Binding sites: 21 - 30; Page 4, Binding sites: 31 - 40; Page 5, Binding sites: 41 - 44;

Binding sites:

The binding sites of Phosphorus atom in the Crystal Structure of A Double-Stranded Dna Containing the Major Adduct of the Anticancer Drug Cisplatin (pdb code 1aio). This binding sites where shown within 5.0 Angstroms radius around Phosphorus atom.
In total 44 binding sites of Phosphorus where determined in the Crystal Structure of A Double-Stranded Dna Containing the Major Adduct of the Anticancer Drug Cisplatin, PDB code: 1aio:
Jump to Phosphorus binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;

Phosphorus binding site 1 out of 44 in 1aio

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Phosphorus binding site 1 out of 44 in the Crystal Structure of A Double-Stranded Dna Containing the Major Adduct of the Anticancer Drug Cisplatin


Mono view


Stereo pair view

A full contact list of Phosphorus with other atoms in the P binding site number 1 of Crystal Structure of A Double-Stranded Dna Containing the Major Adduct of the Anticancer Drug Cisplatin within 5.0Å range:
probe atom residue distance (Å) B Occ
A:P2

b:24.3
occ:1.00
P A:DC2 0.0 24.3 1.0
OP2 A:DC2 1.5 24.6 1.0
OP1 A:DC2 1.5 25.0 1.0
O5' A:DC2 1.6 23.6 1.0
O3' A:DC1 1.6 24.4 1.0
C5' A:DC2 2.6 24.1 1.0
C3' A:DC1 2.7 24.4 1.0
C2' A:DC1 3.5 24.1 1.0
C4' A:DC2 3.9 23.9 1.0
C4' A:DC1 4.0 24.7 1.0
O4' A:DC2 4.3 23.4 1.0
C3' A:DC2 4.5 24.4 1.0
C5' A:DC1 4.5 27.0 1.0
C6 A:DC2 4.6 20.7 1.0
C1' A:DC1 4.9 23.8 1.0
O5' A:DC1 4.9 30.1 1.0
O4' A:DC1 5.0 24.2 1.0

Phosphorus binding site 2 out of 44 in 1aio

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Phosphorus binding site 2 out of 44 in the Crystal Structure of A Double-Stranded Dna Containing the Major Adduct of the Anticancer Drug Cisplatin


Mono view


Stereo pair view

A full contact list of Phosphorus with other atoms in the P binding site number 2 of Crystal Structure of A Double-Stranded Dna Containing the Major Adduct of the Anticancer Drug Cisplatin within 5.0Å range:
probe atom residue distance (Å) B Occ
A:P3

b:26.8
occ:1.00
P A:BRU3 0.0 26.8 1.0
OP2 A:BRU3 1.5 25.4 1.0
OP1 A:BRU3 1.5 27.9 1.0
O5' A:BRU3 1.6 24.2 1.0
O3' A:DC2 1.6 26.1 1.0
C5' A:BRU3 2.6 23.7 1.0
C3' A:DC2 2.7 24.4 1.0
C2' A:DC2 3.4 23.4 1.0
C4' A:BRU3 3.9 23.9 1.0
C4' A:DC2 3.9 23.9 1.0
O4' A:BRU3 4.3 24.0 1.0
C3' A:BRU3 4.4 23.5 1.0
C5' A:DC2 4.5 24.1 1.0
O A:HOH54 4.6 55.0 1.0
O A:HOH85 4.6 55.0 1.0
C6 A:BRU3 4.6 22.9 1.0
BR A:BRU3 4.8 27.6 1.0
C1' A:DC2 4.8 22.9 1.0
O5' A:DC2 4.9 23.6 1.0
O3' A:BRU3 5.0 23.7 1.0
O4' A:DC2 5.0 23.4 1.0

Phosphorus binding site 3 out of 44 in 1aio

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Phosphorus binding site 3 out of 44 in the Crystal Structure of A Double-Stranded Dna Containing the Major Adduct of the Anticancer Drug Cisplatin


Mono view


Stereo pair view

A full contact list of Phosphorus with other atoms in the P binding site number 3 of Crystal Structure of A Double-Stranded Dna Containing the Major Adduct of the Anticancer Drug Cisplatin within 5.0Å range:
probe atom residue distance (Å) B Occ
A:P4

b:24.1
occ:1.00
P A:DC4 0.0 24.1 1.0
OP1 A:DC4 1.5 25.9 1.0
OP2 A:DC4 1.5 23.3 1.0
O3' A:BRU3 1.6 23.7 1.0
O5' A:DC4 1.6 23.0 1.0
C3' A:BRU3 2.5 23.5 1.0
C5' A:DC4 2.7 23.2 1.0
O A:HOH54 3.2 55.0 1.0
O A:HOH85 3.2 55.0 1.0
C2' A:BRU3 3.3 23.6 1.0
C4' A:BRU3 3.8 23.9 1.0
C4' A:DC4 3.9 23.5 1.0
O4' A:DC4 4.2 24.3 1.0
C5' A:BRU3 4.3 23.7 1.0
C3' A:DC4 4.4 22.8 1.0
C6 A:DC4 4.4 22.1 1.0
O5' A:BRU3 4.6 24.2 1.0
C1' A:BRU3 4.7 23.2 1.0
O4' A:BRU3 4.8 24.0 1.0

Phosphorus binding site 4 out of 44 in 1aio

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Phosphorus binding site 4 out of 44 in the Crystal Structure of A Double-Stranded Dna Containing the Major Adduct of the Anticancer Drug Cisplatin


Mono view


Stereo pair view

A full contact list of Phosphorus with other atoms in the P binding site number 4 of Crystal Structure of A Double-Stranded Dna Containing the Major Adduct of the Anticancer Drug Cisplatin within 5.0Å range:
probe atom residue distance (Å) B Occ
A:P5

b:20.2
occ:1.00
P A:DT5 0.0 20.2 1.0
OP1 A:DT5 1.5 22.9 1.0
OP2 A:DT5 1.5 17.9 1.0
O5' A:DT5 1.6 18.5 1.0
O3' A:DC4 1.6 21.1 1.0
C3' A:DC4 2.6 22.8 1.0
C5' A:DT5 2.6 18.4 1.0
C2' A:DC4 3.4 23.8 1.0
C4' A:DC4 3.9 23.5 1.0
C4' A:DT5 3.9 18.6 1.0
O4' A:DT5 4.3 17.8 1.0
C3' A:DT5 4.3 18.3 1.0
O A:HOH60 4.4 69.9 1.0
O A:HOH91 4.4 69.9 1.0
C5' A:DC4 4.4 23.2 1.0
C6 A:DT5 4.4 15.2 1.0
C4' C:DT29 4.6 19.4 1.0
O5' A:DC4 4.8 23.0 1.0
C7 A:DT5 4.8 14.2 1.0
C1' A:DC4 4.8 23.4 1.0
C5' C:DT29 4.8 19.2 1.0
O3' A:DT5 4.9 18.4 1.0
O4' A:DC4 4.9 24.3 1.0

Phosphorus binding site 5 out of 44 in 1aio

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Phosphorus binding site 5 out of 44 in the Crystal Structure of A Double-Stranded Dna Containing the Major Adduct of the Anticancer Drug Cisplatin


Mono view


Stereo pair view

A full contact list of Phosphorus with other atoms in the P binding site number 5 of Crystal Structure of A Double-Stranded Dna Containing the Major Adduct of the Anticancer Drug Cisplatin within 5.0Å range:
probe atom residue distance (Å) B Occ
A:P6

b:19.5
occ:1.00
P A:DG6 0.0 19.5 1.0
OP2 A:DG6 1.4 18.5 1.0
OP1 A:DG6 1.5 21.3 1.0
O3' A:DT5 1.6 18.4 1.0
O5' A:DG6 1.6 19.6 1.0
C3' A:DT5 2.6 18.3 1.0
C5' A:DG6 2.7 19.9 1.0
C2' A:DT5 3.4 17.3 1.0
C4' A:DT5 3.9 18.6 1.0
C4' A:DG6 3.9 20.5 1.0
O A:HOH68 3.9 27.4 1.0
O A:HOH99 3.9 27.4 1.0
O A:HOH66 4.0 57.1 1.0
O A:HOH97 4.0 57.1 1.0
C8 A:DG6 4.2 17.9 1.0
O4' A:DG6 4.2 19.7 1.0
C5' C:DG30 4.3 21.2 1.0
C3' A:DG6 4.3 21.2 1.0
C5' A:DT5 4.4 18.4 1.0
N1 A:CPT49 4.4 22.6 1.0
C4' C:DG30 4.5 20.6 1.0
OP2 A:DG7 4.6 25.7 1.0
O5' A:DT5 4.7 18.5 1.0
C1' A:DT5 4.8 16.9 1.0
O4' A:DT5 5.0 17.8 1.0
N7 A:DG6 5.0 17.7 1.0

Phosphorus binding site 6 out of 44 in 1aio

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Phosphorus binding site 6 out of 44 in the Crystal Structure of A Double-Stranded Dna Containing the Major Adduct of the Anticancer Drug Cisplatin


Mono view


Stereo pair view

A full contact list of Phosphorus with other atoms in the P binding site number 6 of Crystal Structure of A Double-Stranded Dna Containing the Major Adduct of the Anticancer Drug Cisplatin within 5.0Å range:
probe atom residue distance (Å) B Occ
A:P7

b:25.4
occ:1.00
P A:DG7 0.0 25.4 1.0
OP2 A:DG7 1.5 25.7 1.0
OP1 A:DG7 1.5 26.5 1.0
O3' A:DG6 1.5 22.7 1.0
O5' A:DG7 1.6 25.2 1.0
C3' A:DG6 2.5 21.2 1.0
C5' A:DG7 2.7 24.7 1.0
C2' A:DG6 3.5 20.2 1.0
C4' A:DG6 3.7 20.5 1.0
C4' A:DG7 4.0 24.6 1.0
C5' A:DG6 4.2 19.9 1.0
O4' A:DG7 4.3 24.4 1.0
O A:HOH68 4.3 27.4 1.0
O A:HOH99 4.3 27.4 1.0
O5' A:DG6 4.4 19.6 1.0
C1' A:DG6 4.7 19.0 1.0
C3' A:DG7 4.8 24.8 1.0
O4' A:DG6 4.8 19.7 1.0

Phosphorus binding site 7 out of 44 in 1aio

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Phosphorus binding site 7 out of 44 in the Crystal Structure of A Double-Stranded Dna Containing the Major Adduct of the Anticancer Drug Cisplatin


Mono view


Stereo pair view

A full contact list of Phosphorus with other atoms in the P binding site number 7 of Crystal Structure of A Double-Stranded Dna Containing the Major Adduct of the Anticancer Drug Cisplatin within 5.0Å range:
probe atom residue distance (Å) B Occ
A:P8

b:26.1
occ:1.00
P A:DT8 0.0 26.1 1.0
OP1 A:DT8 1.5 27.8 1.0
OP2 A:DT8 1.5 27.4 1.0
O5' A:DT8 1.6 25.9 1.0
O3' A:DG7 1.6 25.4 1.0
C5' A:DT8 2.6 26.7 1.0
C3' A:DG7 2.7 24.8 1.0
C2' A:DG7 3.4 24.5 1.0
C4' A:DT8 3.9 27.6 1.0
C4' A:DG7 3.9 24.6 1.0
O4' A:DT8 4.1 28.0 1.0
C6 A:DT8 4.3 29.2 1.0
C7 A:DT8 4.4 30.6 1.0
C3' A:DT8 4.5 28.7 1.0
C5' A:DG7 4.6 24.7 1.0
C1' A:DG7 4.8 23.8 1.0
O4' A:DG7 4.9 24.4 1.0
C5 A:DT8 4.9 29.9 1.0

Phosphorus binding site 8 out of 44 in 1aio

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Phosphorus binding site 8 out of 44 in the Crystal Structure of A Double-Stranded Dna Containing the Major Adduct of the Anticancer Drug Cisplatin


Mono view


Stereo pair view

A full contact list of Phosphorus with other atoms in the P binding site number 8 of Crystal Structure of A Double-Stranded Dna Containing the Major Adduct of the Anticancer Drug Cisplatin within 5.0Å range:
probe atom residue distance (Å) B Occ
A:P9

b:34.3
occ:1.00
P A:DC9 0.0 34.3 1.0
OP2 A:DC9 1.5 34.6 1.0
OP1 A:DC9 1.5 34.9 1.0
O3' A:DT8 1.6 32.0 1.0
O5' A:DC9 1.6 34.6 1.0
C3' A:DT8 2.6 28.7 1.0
C5' A:DC9 2.7 35.7 1.0
C2' A:DT8 3.2 27.6 1.0
C4' A:DT8 3.8 27.6 1.0
C4' A:DC9 4.0 36.7 1.0
O4' A:DC9 4.3 36.8 1.0
C5' A:DT8 4.5 26.7 1.0
C6 A:DC9 4.5 32.6 1.0
C3' A:DC9 4.6 37.4 1.0
C1' A:DT8 4.6 27.5 1.0
O4' A:DT8 4.8 28.0 1.0
O5' A:DT8 5.0 25.9 1.0

Phosphorus binding site 9 out of 44 in 1aio

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Phosphorus binding site 9 out of 44 in the Crystal Structure of A Double-Stranded Dna Containing the Major Adduct of the Anticancer Drug Cisplatin


Mono view


Stereo pair view

A full contact list of Phosphorus with other atoms in the P binding site number 9 of Crystal Structure of A Double-Stranded Dna Containing the Major Adduct of the Anticancer Drug Cisplatin within 5.0Å range:
probe atom residue distance (Å) B Occ
A:P10

b:40.9
occ:1.00
P A:DT10 0.0 40.9 1.0
OP1 A:DT10 1.5 41.5 1.0
OP2 A:DT10 1.5 40.6 1.0
O3' A:DC9 1.6 39.4 1.0
O5' A:DT10 1.7 40.6 1.0
C3' A:DC9 2.6 37.4 1.0
C5' A:DT10 2.6 41.2 1.0
C2' A:DC9 3.3 37.0 1.0
C4' A:DC9 3.9 36.7 1.0
C4' A:DT10 4.0 42.3 1.0
C6 A:DT10 4.3 34.9 1.0
O4' A:DT10 4.5 41.3 1.0
C5' A:DC9 4.5 35.7 1.0
C3' A:DT10 4.5 43.9 1.0
C7 A:DT10 4.7 34.5 1.0
C1' A:DC9 4.8 36.0 1.0
C2' A:DT10 4.8 41.9 1.0
O4' A:DC9 4.9 36.8 1.0

Phosphorus binding site 10 out of 44 in 1aio

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Phosphorus binding site 10 out of 44 in the Crystal Structure of A Double-Stranded Dna Containing the Major Adduct of the Anticancer Drug Cisplatin


Mono view


Stereo pair view

A full contact list of Phosphorus with other atoms in the P binding site number 10 of Crystal Structure of A Double-Stranded Dna Containing the Major Adduct of the Anticancer Drug Cisplatin within 5.0Å range:
probe atom residue distance (Å) B Occ
A:P11

b:49.3
occ:1.00
P A:DC11 0.0 49.3 1.0
OP1 A:DC11 1.5 49.6 1.0
OP2 A:DC11 1.5 49.2 1.0
O3' A:DT10 1.7 47.1 1.0
O5' A:DC11 1.7 49.0 1.0
C3' A:DT10 2.6 43.9 1.0
C5' A:DC11 2.7 48.3 1.0
C2' A:DT10 3.3 41.9 1.0
C4' A:DT10 4.0 42.3 1.0
C4' A:DC11 4.0 47.5 1.0
C1' A:DT10 4.4 39.2 1.0
C3' A:DC11 4.5 46.7 1.0
O4' A:DC11 4.6 46.8 1.0
C2' A:DC11 4.8 46.1 1.0
O4' A:DT10 4.8 41.3 1.0
C5' A:DT10 4.9 41.2 1.0

Reference:

P.M.Takahara, A.C.Rosenzweig, C.A.Frederick, S.J.Lippard. Crystal Structure of Double-Stranded Dna Containing the Major Adduct of the Anticancer Drug Cisplatin. Nature V. 377 649 1995.
ISSN: ISSN 0028-0836
PubMed: 7566180
DOI: 10.1038/377649A0
Page generated: Fri Sep 25 12:58:57 2020

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