Phosphorus in PDB 1agu: The Solution uc(Nmr) Structure of the C10R Adduct of Benzo[A]Pyrene-Diol-Epoxide at the N6 Position of Adenine of An 11 Base-Pair Oligonucleotide Sequence Coding For Amino Acids 60-62 of the Product of the N-Ras Protooncogene, Minimized Average Structure

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>>> Page 1 <<< Page 2, Binding sites: 11 - 20;

Binding sites:

The binding sites of Phosphorus atom in the The Solution uc(Nmr) Structure of the C10R Adduct of Benzo[A]Pyrene-Diol-Epoxide at the N6 Position of Adenine of An 11 Base-Pair Oligonucleotide Sequence Coding For Amino Acids 60-62 of the Product of the N-Ras Protooncogene, Minimized Average Structure (pdb code 1agu). This binding sites where shown within 5.0 Angstroms radius around Phosphorus atom.
In total 20 binding sites of Phosphorus where determined in the The Solution uc(Nmr) Structure of the C10R Adduct of Benzo[A]Pyrene-Diol-Epoxide at the N6 Position of Adenine of An 11 Base-Pair Oligonucleotide Sequence Coding For Amino Acids 60-62 of the Product of the N-Ras Protooncogene, Minimized Average Structure, PDB code: 1agu:
Jump to Phosphorus binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;

Phosphorus binding site 1 out of 20 in the The Solution uc(Nmr) Structure of the C10R Adduct of Benzo[A]Pyrene-Diol-Epoxide at the N6 Position of Adenine of An 11 Base-Pair Oligonucleotide Sequence Coding For Amino Acids 60-62 of the Product of the N-Ras Protooncogene, Minimized Average Structure


Mono view


Stereo pair view

A full contact list of Phosphorus with other atoms in the P binding site number 1 of The Solution uc(Nmr) Structure of the C10R Adduct of Benzo[A]Pyrene-Diol-Epoxide at the N6 Position of Adenine of An 11 Base-Pair Oligonucleotide Sequence Coding For Amino Acids 60-62 of the Product of the N-Ras Protooncogene, Minimized Average Structure within 5.0Å range: probe atom residue distance (Å) B Occ A:P2 b:0.8 occ:1.00 P A:DG2 0.0 0.8 1.0 OP2 A:DG2 1.5 0.8 1.0 OP1 A:DG2 1.5 0.9 1.0 O3' A:DC1 1.6 0.8 1.0 O5' A:DG2 1.6 0.7 1.0 H5'' A:DG2 2.5 1.2 1.0 C5' A:DG2 2.5 0.7 1.0 C3' A:DC1 2.6 0.8 1.0 H5' A:DG2 2.7 1.2 1.0 H2'' A:DC1 2.7 0.6 1.0 H3' A:DC1 2.9 0.8 1.0 C2' A:DC1 3.1 0.7 1.0 H2' A:DC1 3.5 0.7 1.0 H3' A:DG2 3.9 0.5 1.0 C4' A:DC1 3.9 0.9 1.0 C4' A:DG2 3.9 0.5 1.0 H4' A:DC1 4.0 0.9 1.0 H8 A:DG2 4.1 0.4 1.0 C1' A:DC1 4.4 0.7 1.0 C3' A:DG2 4.5 0.4 1.0 O4' A:DG2 4.5 0.5 1.0 H5'' A:DC1 4.6 1.1 1.0 H1' A:DC1 4.6 0.7 1.0 H4' A:DG2 4.6 0.6 1.0 O4' A:DC1 4.8 0.9 1.0 C5' A:DC1 4.8 1.1 1.0

Phosphorus binding site 2 out of 20 in the The Solution uc(Nmr) Structure of the C10R Adduct of Benzo[A]Pyrene-Diol-Epoxide at the N6 Position of Adenine of An 11 Base-Pair Oligonucleotide Sequence Coding For Amino Acids 60-62 of the Product of the N-Ras Protooncogene, Minimized Average Structure


Mono view


Stereo pair view

A full contact list of Phosphorus with other atoms in the P binding site number 2 of The Solution uc(Nmr) Structure of the C10R Adduct of Benzo[A]Pyrene-Diol-Epoxide at the N6 Position of Adenine of An 11 Base-Pair Oligonucleotide Sequence Coding For Amino Acids 60-62 of the Product of the N-Ras Protooncogene, Minimized Average Structure within 5.0Å range: probe atom residue distance (Å) B Occ A:P3 b:0.4 occ:1.00 P A:DG3 0.0 0.4 1.0 OP1 A:DG3 1.5 0.5 1.0 OP2 A:DG3 1.5 0.5 1.0 O5' A:DG3 1.6 0.4 1.0 O3' A:DG2 1.6 0.4 1.0 C5' A:DG3 2.6 0.4 1.0 C3' A:DG2 2.6 0.4 1.0 H5' A:DG3 2.8 0.4 1.0 H3' A:DG2 2.8 0.5 1.0 H2'' A:DG2 2.8 0.6 1.0 H5'' A:DG3 2.9 0.4 1.0 C2' A:DG2 3.2 0.4 1.0 H2' A:DG2 3.5 0.6 1.0 H8 A:DG3 3.6 0.3 1.0 H3' A:DG3 3.8 0.4 1.0 C4' A:DG2 3.9 0.5 1.0 C4' A:DG3 4.0 0.4 1.0 H4' A:DG2 4.0 0.6 1.0 O4' A:DG3 4.4 0.4 1.0 C3' A:DG3 4.4 0.4 1.0 H5'' A:DG2 4.5 1.2 1.0 C1' A:DG2 4.6 0.4 1.0 C8 A:DG3 4.7 0.3 1.0 C5' A:DG2 4.7 0.7 1.0 H4' A:DG3 4.8 0.4 1.0 H1' A:DG2 4.9 0.6 1.0 O4' A:DG2 4.9 0.5 1.0 H2' A:DG3 4.9 0.3 1.0

Phosphorus binding site 3 out of 20 in the The Solution uc(Nmr) Structure of the C10R Adduct of Benzo[A]Pyrene-Diol-Epoxide at the N6 Position of Adenine of An 11 Base-Pair Oligonucleotide Sequence Coding For Amino Acids 60-62 of the Product of the N-Ras Protooncogene, Minimized Average Structure


Mono view


Stereo pair view

A full contact list of Phosphorus with other atoms in the P binding site number 3 of The Solution uc(Nmr) Structure of the C10R Adduct of Benzo[A]Pyrene-Diol-Epoxide at the N6 Position of Adenine of An 11 Base-Pair Oligonucleotide Sequence Coding For Amino Acids 60-62 of the Product of the N-Ras Protooncogene, Minimized Average Structure within 5.0Å range: probe atom residue distance (Å) B Occ A:P4 b:0.5 occ:1.00 P A:DA4 0.0 0.5 1.0 OP1 A:DA4 1.5 0.5 1.0 OP2 A:DA4 1.5 0.4 1.0 O5' A:DA4 1.6 0.5 1.0 O3' A:DG3 1.6 0.4 1.0 H2'' A:DG3 2.6 0.4 1.0 C5' A:DA4 2.6 0.5 1.0 C3' A:DG3 2.7 0.4 1.0 H5'' A:DA4 2.8 0.5 1.0 H5' A:DA4 2.9 0.5 1.0 H3' A:DG3 3.0 0.4 1.0 C2' A:DG3 3.1 0.4 1.0 H8 A:DA4 3.4 0.4 1.0 H2' A:DG3 3.6 0.3 1.0 H3' A:DA4 3.8 0.5 1.0 C4' A:DG3 4.0 0.4 1.0 C4' A:DA4 4.0 0.5 1.0 H4' A:DG3 4.0 0.4 1.0 C1' A:DG3 4.4 0.3 1.0 C3' A:DA4 4.4 0.5 1.0 H2' A:DA4 4.4 0.4 1.0 C8 A:DA4 4.4 0.4 1.0 H1' A:DG3 4.5 0.4 1.0 O4' A:DA4 4.5 0.5 1.0 H4' A:DA4 4.8 0.5 1.0 H5'' A:DG3 4.8 0.4 1.0 O4' A:DG3 4.8 0.4 1.0 C2' A:DA4 4.9 0.4 1.0 C5' A:DG3 4.9 0.4 1.0

Phosphorus binding site 4 out of 20 in the The Solution uc(Nmr) Structure of the C10R Adduct of Benzo[A]Pyrene-Diol-Epoxide at the N6 Position of Adenine of An 11 Base-Pair Oligonucleotide Sequence Coding For Amino Acids 60-62 of the Product of the N-Ras Protooncogene, Minimized Average Structure


Mono view


Stereo pair view

A full contact list of Phosphorus with other atoms in the P binding site number 4 of The Solution uc(Nmr) Structure of the C10R Adduct of Benzo[A]Pyrene-Diol-Epoxide at the N6 Position of Adenine of An 11 Base-Pair Oligonucleotide Sequence Coding For Amino Acids 60-62 of the Product of the N-Ras Protooncogene, Minimized Average Structure within 5.0Å range: probe atom residue distance (Å) B Occ A:P5 b:0.5 occ:1.00 P A:DC5 0.0 0.5 1.0 OP1 A:DC5 1.5 0.5 1.0 OP2 A:DC5 1.5 0.5 1.0 O5' A:DC5 1.6 0.5 1.0 O3' A:DA4 1.6 0.5 1.0 H2'' A:DA4 2.5 0.4 1.0 C5' A:DC5 2.6 0.4 1.0 C3' A:DA4 2.7 0.5 1.0 H5'' A:DC5 2.9 0.4 1.0 H5' A:DC5 2.9 0.4 1.0 H3' A:DA4 3.0 0.5 1.0 C2' A:DA4 3.1 0.4 1.0 H2' A:DA4 3.7 0.4 1.0 C4' A:DA4 3.9 0.5 1.0 C4' A:DC5 4.0 0.4 1.0 H4' A:DA4 4.0 0.5 1.0 H1' A:DA4 4.2 0.4 1.0 C1' A:DA4 4.2 0.4 1.0 H4' A:DC5 4.2 0.4 1.0 H6 A:DC5 4.3 0.4 1.0 O4' A:DC5 4.4 0.4 1.0 O4' A:DA4 4.6 0.5 1.0 H5'' A:DA4 5.0 0.5 1.0 H3' A:DC5 5.0 0.4 1.0

Phosphorus binding site 5 out of 20 in the The Solution uc(Nmr) Structure of the C10R Adduct of Benzo[A]Pyrene-Diol-Epoxide at the N6 Position of Adenine of An 11 Base-Pair Oligonucleotide Sequence Coding For Amino Acids 60-62 of the Product of the N-Ras Protooncogene, Minimized Average Structure


Mono view


Stereo pair view

A full contact list of Phosphorus with other atoms in the P binding site number 5 of The Solution uc(Nmr) Structure of the C10R Adduct of Benzo[A]Pyrene-Diol-Epoxide at the N6 Position of Adenine of An 11 Base-Pair Oligonucleotide Sequence Coding For Amino Acids 60-62 of the Product of the N-Ras Protooncogene, Minimized Average Structure within 5.0Å range: probe atom residue distance (Å) B Occ A:P6 b:0.5 occ:1.00 P A:E6 0.0 0.5 1.0 OP1 A:E6 1.5 0.5 1.0 OP2 A:E6 1.5 0.5 1.0 O3' A:DC5 1.6 0.4 1.0 O5' A:E6 1.6 0.5 1.0 H8 A:E6 2.6 0.5 1.0 C5' A:E6 2.7 0.5 1.0 C3' A:DC5 2.7 0.4 1.0 H5' A:E6 2.7 0.5 1.0 H3' A:DC5 2.8 0.4 1.0 H4' A:DC5 3.0 0.4 1.0 H5'' A:E6 3.3 0.5 1.0 C4' A:DC5 3.4 0.4 1.0 H5' A:DC5 3.7 0.4 1.0 C8 A:E6 3.7 0.4 1.0 C4' A:E6 3.8 0.5 1.0 C2' A:DC5 3.9 0.4 1.0 H2'' A:DC5 3.9 0.4 1.0 O4' A:E6 3.9 0.5 1.0 H3' A:E6 4.0 0.5 1.0 C5' A:DC5 4.1 0.4 1.0 C3' A:E6 4.4 0.5 1.0 N7 A:E6 4.4 0.4 1.0 N9 A:E6 4.5 0.4 1.0 H2' A:DC5 4.5 0.4 1.0 O4' A:DC5 4.6 0.4 1.0 H4' A:E6 4.7 0.5 1.0 C1' A:E6 4.7 0.5 1.0 H5'' A:DC5 4.7 0.4 1.0 H2' A:E6 4.7 0.5 1.0 C1' A:DC5 4.9 0.4 1.0 C2' A:E6 4.9 0.5 1.0

Phosphorus binding site 6 out of 20 in the The Solution uc(Nmr) Structure of the C10R Adduct of Benzo[A]Pyrene-Diol-Epoxide at the N6 Position of Adenine of An 11 Base-Pair Oligonucleotide Sequence Coding For Amino Acids 60-62 of the Product of the N-Ras Protooncogene, Minimized Average Structure


Mono view


Stereo pair view

A full contact list of Phosphorus with other atoms in the P binding site number 6 of The Solution uc(Nmr) Structure of the C10R Adduct of Benzo[A]Pyrene-Diol-Epoxide at the N6 Position of Adenine of An 11 Base-Pair Oligonucleotide Sequence Coding For Amino Acids 60-62 of the Product of the N-Ras Protooncogene, Minimized Average Structure within 5.0Å range: probe atom residue distance (Å) B Occ A:P7 b:0.5 occ:1.00 P A:DA7 0.0 0.5 1.0 OP1 A:DA7 1.5 0.5 1.0 OP2 A:DA7 1.5 0.5 1.0 O5' A:DA7 1.6 0.5 1.0 O3' A:E6 1.6 0.5 1.0 C5' A:DA7 2.6 0.5 1.0 C3' A:E6 2.7 0.5 1.0 H2'' A:E6 2.7 0.5 1.0 H5'' A:DA7 2.8 0.5 1.0 H3' A:E6 2.9 0.5 1.0 H5' A:DA7 3.0 0.5 1.0 C2' A:E6 3.1 0.5 1.0 H2' A:E6 3.6 0.5 1.0 H3' A:DA7 3.6 0.5 1.0 C4' A:DA7 4.0 0.5 1.0 C4' A:E6 4.0 0.5 1.0 H4' A:E6 4.0 0.5 1.0 H8 A:DA7 4.2 0.4 1.0 C3' A:DA7 4.2 0.5 1.0 H2' A:DA7 4.3 0.5 1.0 C1' A:E6 4.4 0.5 1.0 O4' A:DA7 4.6 0.4 1.0 H1' A:E6 4.6 0.5 1.0 H4' A:DA7 4.7 0.5 1.0 H5'' A:E6 4.8 0.5 1.0 C2' A:DA7 4.8 0.5 1.0 O4' A:E6 4.8 0.5 1.0 C5' A:E6 4.9 0.5 1.0

Phosphorus binding site 7 out of 20 in the The Solution uc(Nmr) Structure of the C10R Adduct of Benzo[A]Pyrene-Diol-Epoxide at the N6 Position of Adenine of An 11 Base-Pair Oligonucleotide Sequence Coding For Amino Acids 60-62 of the Product of the N-Ras Protooncogene, Minimized Average Structure


Mono view


Stereo pair view

A full contact list of Phosphorus with other atoms in the P binding site number 7 of The Solution uc(Nmr) Structure of the C10R Adduct of Benzo[A]Pyrene-Diol-Epoxide at the N6 Position of Adenine of An 11 Base-Pair Oligonucleotide Sequence Coding For Amino Acids 60-62 of the Product of the N-Ras Protooncogene, Minimized Average Structure within 5.0Å range: probe atom residue distance (Å) B Occ A:P8 b:0.5 occ:1.00 P A:DG8 0.0 0.5 1.0 OP2 A:DG8 1.5 0.5 1.0 OP1 A:DG8 1.5 0.5 1.0 O5' A:DG8 1.6 0.5 1.0 O3' A:DA7 1.6 0.5 1.0 H2'' A:DA7 2.6 0.5 1.0 C5' A:DG8 2.6 0.5 1.0 C3' A:DA7 2.7 0.5 1.0 H5' A:DG8 2.8 0.5 1.0 H3' A:DA7 2.9 0.5 1.0 H5'' A:DG8 3.0 0.5 1.0 C2' A:DA7 3.1 0.5 1.0 H2' A:DA7 3.8 0.5 1.0 H3' A:DG8 4.0 0.4 1.0 C4' A:DG8 4.0 0.4 1.0 C4' A:DA7 4.0 0.5 1.0 H8 A:DG8 4.0 0.4 1.0 H4' A:DA7 4.0 0.5 1.0 H1' A:DA7 4.2 0.4 1.0 C1' A:DA7 4.3 0.4 1.0 O4' A:DG8 4.3 0.4 1.0 C3' A:DG8 4.5 0.4 1.0 O4' A:DA7 4.7 0.4 1.0 H4' A:DG8 4.8 0.4 1.0 H5'' A:DA7 4.9 0.5 1.0

Phosphorus binding site 8 out of 20 in the The Solution uc(Nmr) Structure of the C10R Adduct of Benzo[A]Pyrene-Diol-Epoxide at the N6 Position of Adenine of An 11 Base-Pair Oligonucleotide Sequence Coding For Amino Acids 60-62 of the Product of the N-Ras Protooncogene, Minimized Average Structure


Mono view


Stereo pair view

A full contact list of Phosphorus with other atoms in the P binding site number 8 of The Solution uc(Nmr) Structure of the C10R Adduct of Benzo[A]Pyrene-Diol-Epoxide at the N6 Position of Adenine of An 11 Base-Pair Oligonucleotide Sequence Coding For Amino Acids 60-62 of the Product of the N-Ras Protooncogene, Minimized Average Structure within 5.0Å range: probe atom residue distance (Å) B Occ A:P9 b:0.5 occ:1.00 P A:DA9 0.0 0.5 1.0 OP2 A:DA9 1.5 0.5 1.0 OP1 A:DA9 1.5 0.6 1.0 O5' A:DA9 1.6 0.4 1.0 O3' A:DG8 1.6 0.5 1.0 C5' A:DA9 2.6 0.5 1.0 C3' A:DG8 2.7 0.4 1.0 H2'' A:DG8 2.7 0.4 1.0 H5'' A:DA9 2.9 0.5 1.0 H5' A:DA9 2.9 0.5 1.0 H3' A:DG8 3.0 0.4 1.0 H8 A:DA9 3.0 0.4 1.0 C2' A:DG8 3.1 0.4 1.0 H2' A:DG8 3.4 0.4 1.0 H3' A:DA9 3.8 0.4 1.0 C4' A:DG8 4.0 0.4 1.0 C4' A:DA9 4.0 0.5 1.0 H4' A:DG8 4.0 0.4 1.0 C8 A:DA9 4.1 0.3 1.0 C3' A:DA9 4.4 0.4 1.0 C1' A:DG8 4.4 0.4 1.0 O4' A:DA9 4.4 0.4 1.0 H5'' A:DG8 4.6 0.5 1.0 H1' A:DG8 4.7 0.4 1.0 H2' A:DA9 4.8 0.4 1.0 H4' A:DA9 4.8 0.5 1.0 N7 A:DA9 4.8 0.3 1.0 O4' A:DG8 4.9 0.4 1.0 C5' A:DG8 4.9 0.5 1.0 N9 A:DA9 5.0 0.3 1.0

Phosphorus binding site 9 out of 20 in the The Solution uc(Nmr) Structure of the C10R Adduct of Benzo[A]Pyrene-Diol-Epoxide at the N6 Position of Adenine of An 11 Base-Pair Oligonucleotide Sequence Coding For Amino Acids 60-62 of the Product of the N-Ras Protooncogene, Minimized Average Structure


Mono view


Stereo pair view

A full contact list of Phosphorus with other atoms in the P binding site number 9 of The Solution uc(Nmr) Structure of the C10R Adduct of Benzo[A]Pyrene-Diol-Epoxide at the N6 Position of Adenine of An 11 Base-Pair Oligonucleotide Sequence Coding For Amino Acids 60-62 of the Product of the N-Ras Protooncogene, Minimized Average Structure within 5.0Å range: probe atom residue distance (Å) B Occ A:P10 b:0.5 occ:1.00 P A:DA10 0.0 0.5 1.0 OP2 A:DA10 1.5 0.5 1.0 OP1 A:DA10 1.5 0.6 1.0 O3' A:DA9 1.6 0.5 1.0 O5' A:DA10 1.6 0.5 1.0 C5' A:DA10 2.6 0.6 1.0 C3' A:DA9 2.6 0.4 1.0 H2'' A:DA9 2.7 0.4 1.0 H5'' A:DA10 2.8 0.7 1.0 H3' A:DA9 2.9 0.4 1.0 H5' A:DA10 3.0 0.6 1.0 C2' A:DA9 3.1 0.4 1.0 H2' A:DA9 3.6 0.4 1.0 H3' A:DA10 3.6 0.6 1.0 H8 A:DA10 3.7 0.4 1.0 C4' A:DA10 3.9 0.6 1.0 C4' A:DA9 3.9 0.5 1.0 H4' A:DA9 4.0 0.5 1.0 C3' A:DA10 4.3 0.6 1.0 C1' A:DA9 4.4 0.4 1.0 O4' A:DA10 4.5 0.5 1.0 H1' A:DA9 4.6 0.4 1.0 H2' A:DA10 4.6 0.5 1.0 C8 A:DA10 4.6 0.4 1.0 H4' A:DA10 4.7 0.7 1.0 H5'' A:DA9 4.8 0.5 1.0 O4' A:DA9 4.8 0.4 1.0 C5' A:DA9 4.9 0.5 1.0 C2' A:DA10 5.0 0.6 1.0

Phosphorus binding site 10 out of 20 in the The Solution uc(Nmr) Structure of the C10R Adduct of Benzo[A]Pyrene-Diol-Epoxide at the N6 Position of Adenine of An 11 Base-Pair Oligonucleotide Sequence Coding For Amino Acids 60-62 of the Product of the N-Ras Protooncogene, Minimized Average Structure


Mono view


Stereo pair view

A full contact list of Phosphorus with other atoms in the P binding site number 10 of The Solution uc(Nmr) Structure of the C10R Adduct of Benzo[A]Pyrene-Diol-Epoxide at the N6 Position of Adenine of An 11 Base-Pair Oligonucleotide Sequence Coding For Amino Acids 60-62 of the Product of the N-Ras Protooncogene, Minimized Average Structure within 5.0Å range: probe atom residue distance (Å) B Occ A:P11 b:1.0 occ:1.00 P A:DG11 0.0 1.0 1.0 OP2 A:DG11 1.5 1.0 1.0 OP1 A:DG11 1.5 1.1 1.0 O3' A:DA10 1.6 0.8 1.0 O5' A:DG11 1.6 1.1 1.0 C5' A:DG11 2.6 1.2 1.0 C3' A:DA10 2.6 0.6 1.0 H5' A:DG11 2.8 1.2 1.0 H2'' A:DA10 2.8 0.6 1.0 H3' A:DA10 2.8 0.6 1.0 H5'' A:DG11 2.8 1.4 1.0 C2' A:DA10 3.2 0.6 1.0 H2' A:DA10 3.7 0.5 1.0 H3' A:DG11 3.8 1.4 1.0 H8 A:DG11 3.8 0.9 1.0 C4' A:DA10 3.9 0.6 1.0 C4' A:DG11 3.9 1.3 1.0 H4' A:DA10 4.0 0.7 1.0 O4' A:DG11 4.4 1.1 1.0 C3' A:DG11 4.4 1.4 1.0 C1' A:DA10 4.5 0.5 1.0 H5'' A:DA10 4.6 0.7 1.0 H1' A:DA10 4.7 0.5 1.0 H4' A:DG11 4.7 1.5 1.0 O4' A:DA10 4.8 0.5 1.0 C5' A:DA10 4.8 0.6 1.0 C8 A:DG11 4.8 0.9 1.0 H2' A:DG11 5.0 1.3 1.0

I.S.Zegar, S.J.Kim, T.N.Johansen, P.J.Horton, C.M.Harris, T.M.Harris, M.P.Stone. Adduction of the Human N-Ras Codon 61 Sequence with (-)-(7S,8R,9R,10S)-7,8-Dihydroxy-9,10-Epoxy-7, 8,9,10-Tetrahydrobenzo[A] Pyrene: Structural Refinement of the Intercalated Srsr(61,2) (-)-(7S,8R,9S,1 0R)-N6-[10-(7,8,9,10- Tetrahydrobenzo[A]Pyrenyl)]-2'-Deoxyadenosyl Adduct From 1H uc(Nmr) Biochemistry V. 35 6212 1996.
ISSN: ISSN 0006-2960
PubMed: 8639561
DOI: 10.1021/BI9524732