Phosphorus in PDB 1ad5: Src Family Kinase Hck-Amp-Pnp Complex

Enzymatic activity of Src Family Kinase Hck-Amp-Pnp Complex

All present enzymatic activity of Src Family Kinase Hck-Amp-Pnp Complex:
2.7.1.112;

Protein crystallography data

The structure of Src Family Kinase Hck-Amp-Pnp Complex, PDB code: 1ad5 was solved by F.Sicheri, I.Moarefi, J.Kuriyan, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 18.00 / 2.60
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 72.767, 92.360, 178.290, 90.00, 90.00, 90.00
R / Rfree (%) 23.9 / 30.7

Phosphorus Binding Sites:

The binding sites of Phosphorus atom in the Src Family Kinase Hck-Amp-Pnp Complex (pdb code 1ad5). This binding sites where shown within 5.0 Angstroms radius around Phosphorus atom.
In total 8 binding sites of Phosphorus where determined in the Src Family Kinase Hck-Amp-Pnp Complex, PDB code: 1ad5:
Jump to Phosphorus binding site number: 1; 2; 3; 4; 5; 6; 7; 8;

Phosphorus binding site 1 out of 8 in 1ad5

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Phosphorus binding site 1 out of 8 in the Src Family Kinase Hck-Amp-Pnp Complex


Mono view


Stereo pair view

A full contact list of Phosphorus with other atoms in the P binding site number 1 of Src Family Kinase Hck-Amp-Pnp Complex within 5.0Å range:
probe atom residue distance (Å) B Occ
A:P527

b:30.5
occ:1.00
 P A:PTR527 0.0 30.5 1.0
O1P A:PTR527 1.5 28.7 1.0
O3P A:PTR527 1.5 25.4 1.0
O2P A:PTR527 1.5 25.0 1.0
OH A:PTR527 1.6 29.5 1.0
H A:GLU178 2.7 0.0 1.0
CZ A:PTR527 2.7 27.8 1.0
HZ3 A:LYS203 3.1 0.0 1.0
HG A:SER177 3.1 0.0 1.0
H A:THR179 3.1 0.0 1.0
HH12 A:ARG175 3.3 0.0 1.0
CE1 A:PTR527 3.5 24.1 1.0
N A:GLU178 3.5 40.2 1.0
HH22 A:ARG175 3.5 0.0 1.0
OG A:SER177 3.5 36.5 1.0
CE2 A:PTR527 3.6 27.8 1.0
OG1 A:THR179 3.6 35.2 1.0
OG A:SER185 3.7 31.2 1.0
HG1 A:THR179 3.9 0.0 1.0
CB A:GLU178 4.0 40.8 1.0
NZ A:LYS203 4.0 39.4 1.0
N A:THR179 4.0 42.7 1.0
NH1 A:ARG175 4.1 26.2 1.0
CA A:SER177 4.2 38.4 1.0
CA A:GLU178 4.2 41.3 1.0
NH2 A:ARG175 4.3 24.1 1.0
HZ2 A:LYS203 4.3 0.0 1.0
C A:SER177 4.3 39.4 1.0
CB A:SER185 4.4 31.2 1.0
CB A:SER177 4.4 37.5 1.0
HG A:SER185 4.5 0.0 1.0
H A:THR180 4.5 0.0 1.0
CE A:LYS203 4.6 39.5 1.0
CZ A:ARG175 4.6 25.4 1.0
C A:GLU178 4.7 41.9 1.0
CD A:ARG155 4.7 23.1 1.0
HH11 A:ARG155 4.7 0.0 1.0
HH11 A:ARG175 4.7 0.0 1.0
CB A:THR179 4.7 38.1 1.0
CD1 A:PTR527 4.7 23.8 1.0
HZ1 A:LYS203 4.8 0.0 1.0
OE1 A:GLU178 4.8 46.6 1.0
CD2 A:PTR527 4.8 26.8 1.0
CG A:ARG155 4.8 25.8 1.0
CG2 A:THR179 4.9 35.0 1.0
CB A:ARG155 4.9 26.3 1.0

Phosphorus binding site 2 out of 8 in 1ad5

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Phosphorus binding site 2 out of 8 in the Src Family Kinase Hck-Amp-Pnp Complex


Mono view


Stereo pair view

A full contact list of Phosphorus with other atoms in the P binding site number 2 of Src Family Kinase Hck-Amp-Pnp Complex within 5.0Å range:
probe atom residue distance (Å) B Occ
B:P527

b:29.0
occ:1.00
 P B:PTR527 0.0 29.0 1.0
O3P B:PTR527 1.5 28.2 1.0
O1P B:PTR527 1.5 26.4 1.0
O2P B:PTR527 1.5 24.6 1.0
OH B:PTR527 1.6 31.7 1.0
CZ B:PTR527 2.7 31.6 1.0
H B:GLU178 2.8 0.0 1.0
HZ3 B:LYS203 3.0 0.0 1.0
H B:THR179 3.1 0.0 1.0
HG B:SER177 3.1 0.0 1.0
HH12 B:ARG175 3.3 0.0 1.0
CE1 B:PTR527 3.4 32.5 1.0
OG B:SER177 3.5 41.5 1.0
N B:GLU178 3.5 39.4 1.0
CE2 B:PTR527 3.6 32.0 1.0
HH22 B:ARG175 3.6 0.0 1.0
OG1 B:THR179 3.6 36.1 1.0
HG1 B:THR179 3.8 0.0 1.0
OG B:SER185 3.8 16.2 1.0
N B:THR179 4.0 41.4 1.0
NZ B:LYS203 4.0 19.8 1.0
CB B:GLU178 4.0 41.9 1.0
NH1 B:ARG175 4.1 21.2 1.0
HZ2 B:LYS203 4.2 0.0 1.0
CA B:GLU178 4.3 40.9 1.0
CA B:SER177 4.3 37.4 1.0
NH2 B:ARG175 4.3 23.8 1.0
C B:SER177 4.4 38.1 1.0
H B:THR180 4.4 0.0 1.0
CE B:LYS203 4.5 23.4 1.0
CB B:SER177 4.5 38.4 1.0
HH11 B:ARG155 4.5 0.0 1.0
CB B:SER185 4.5 16.6 1.0
CG2 B:THR179 4.6 33.0 1.0
CB B:THR179 4.6 37.3 1.0
C B:GLU178 4.6 42.2 1.0
HG B:SER185 4.6 0.0 1.0
CZ B:ARG175 4.6 19.0 1.0
CD1 B:PTR527 4.7 30.9 1.0
CD B:ARG155 4.7 32.5 1.0
HZ1 B:LYS203 4.7 0.0 1.0
OE1 B:GLU178 4.7 47.2 1.0
CD2 B:PTR527 4.8 31.6 1.0
HH11 B:ARG175 4.8 0.0 1.0
CG B:ARG155 4.9 28.6 1.0
CB B:ARG155 4.9 26.6 1.0
CD B:LYS203 4.9 23.0 1.0
CA B:THR179 5.0 39.1 1.0

Phosphorus binding site 3 out of 8 in 1ad5

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Phosphorus binding site 3 out of 8 in the Src Family Kinase Hck-Amp-Pnp Complex


Mono view


Stereo pair view

A full contact list of Phosphorus with other atoms in the P binding site number 3 of Src Family Kinase Hck-Amp-Pnp Complex within 5.0Å range:
probe atom residue distance (Å) B Occ
A:P1

b:86.7
occ:1.00
 PG A:ANP1 0.0 86.7 1.0
O3G A:ANP1 1.5 86.3 1.0
O2G A:ANP1 1.5 84.4 1.0
O1G A:ANP1 1.5 86.6 1.0
N3B A:ANP1 1.6 77.6 1.0
PB A:ANP1 3.0 69.9 1.0
O2B A:ANP1 3.4 71.0 1.0
O3A A:ANP1 3.4 60.8 1.0
O1B A:ANP1 4.1 68.4 1.0
CA A:GLY276 4.2 49.1 1.0
PA A:ANP1 4.8 50.7 1.0
HH22 A:ARG388 4.8 0.0 1.0
O5' A:ANP1 5.0 43.0 1.0

Phosphorus binding site 4 out of 8 in 1ad5

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Phosphorus binding site 4 out of 8 in the Src Family Kinase Hck-Amp-Pnp Complex


Mono view


Stereo pair view

A full contact list of Phosphorus with other atoms in the P binding site number 4 of Src Family Kinase Hck-Amp-Pnp Complex within 5.0Å range:
probe atom residue distance (Å) B Occ
A:P1

b:69.9
occ:1.00
 PB A:ANP1 0.0 69.9 1.0
O1B A:ANP1 1.5 68.4 1.0
O2B A:ANP1 1.5 71.0 1.0
O3A A:ANP1 1.5 60.8 1.0
N3B A:ANP1 1.6 77.6 1.0
PA A:ANP1 2.9 50.7 1.0
PG A:ANP1 3.0 86.7 1.0
O3G A:ANP1 3.2 86.3 1.0
CA A:CA3 3.4 22.4 1.0
O2A A:ANP1 3.5 51.7 1.0
O1A A:ANP1 3.6 50.8 1.0
O2G A:ANP1 3.6 84.4 1.0
HH22 A:ARG388 3.8 0.0 1.0
O5' A:ANP1 3.9 43.0 1.0
O1G A:ANP1 4.0 86.6 1.0
HD21 A:ASN391 4.1 0.0 1.0
C5' A:ANP1 4.2 35.6 1.0
HZ3 A:LYS295 4.3 0.0 1.0
NH2 A:ARG388 4.5 33.0 1.0
HH21 A:ARG388 4.6 0.0 1.0
HD22 A:ASN391 4.7 0.0 1.0
ND2 A:ASN391 4.7 15.5 1.0

Phosphorus binding site 5 out of 8 in 1ad5

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Phosphorus binding site 5 out of 8 in the Src Family Kinase Hck-Amp-Pnp Complex


Mono view


Stereo pair view

A full contact list of Phosphorus with other atoms in the P binding site number 5 of Src Family Kinase Hck-Amp-Pnp Complex within 5.0Å range:
probe atom residue distance (Å) B Occ
A:P1

b:50.7
occ:1.00
 PA A:ANP1 0.0 50.7 1.0
O2A A:ANP1 1.5 51.7 1.0
O1A A:ANP1 1.5 50.8 1.0
O5' A:ANP1 1.6 43.0 1.0
O3A A:ANP1 1.6 60.8 1.0
C5' A:ANP1 2.6 35.6 1.0
PB A:ANP1 2.9 69.9 1.0
O2B A:ANP1 3.4 71.0 1.0
HZ3 A:LYS295 3.6 0.0 1.0
O1B A:ANP1 3.6 68.4 1.0
CA A:CA3 3.6 22.4 1.0
C4' A:ANP1 3.9 30.2 1.0
CG2 A:VAL281 3.9 25.6 1.0
CE A:LYS295 4.0 33.6 1.0
HZ2 A:LYS295 4.0 0.0 1.0
N3B A:ANP1 4.0 77.6 1.0
NZ A:LYS295 4.1 34.9 1.0
O4' A:ANP1 4.2 26.0 1.0
O2G A:ANP1 4.5 84.4 1.0
H A:GLY276 4.7 0.0 1.0
C8 A:ANP1 4.7 19.5 1.0
PG A:ANP1 4.8 86.7 1.0
O3G A:ANP1 4.8 86.3 1.0

Phosphorus binding site 6 out of 8 in 1ad5

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Phosphorus binding site 6 out of 8 in the Src Family Kinase Hck-Amp-Pnp Complex


Mono view


Stereo pair view

A full contact list of Phosphorus with other atoms in the P binding site number 6 of Src Family Kinase Hck-Amp-Pnp Complex within 5.0Å range:
probe atom residue distance (Å) B Occ
B:P532

b:86.5
occ:1.00
 PG B:ANP532 0.0 86.5 1.0
O2G B:ANP532 1.5 86.5 1.0
O3G B:ANP532 1.5 84.2 1.0
O1G B:ANP532 1.5 86.8 1.0
N3B B:ANP532 1.6 78.8 1.0
PB B:ANP532 2.9 72.5 1.0
O3A B:ANP532 3.0 66.9 1.0
O1B B:ANP532 3.6 72.7 1.0
C5' B:ANP532 4.0 48.0 1.0
O2B B:ANP532 4.0 73.4 1.0
O5' B:ANP532 4.3 54.6 1.0
PA B:ANP532 4.4 59.9 1.0
HH22 B:ARG388 4.5 0.0 1.0
HH12 B:ARG388 4.6 0.0 1.0
C4' B:ANP532 4.8 44.5 1.0
CB B:ALA390 4.9 22.4 1.0

Phosphorus binding site 7 out of 8 in 1ad5

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Phosphorus binding site 7 out of 8 in the Src Family Kinase Hck-Amp-Pnp Complex


Mono view


Stereo pair view

A full contact list of Phosphorus with other atoms in the P binding site number 7 of Src Family Kinase Hck-Amp-Pnp Complex within 5.0Å range:
probe atom residue distance (Å) B Occ
B:P532

b:72.5
occ:1.00
 PB B:ANP532 0.0 72.5 1.0
O1B B:ANP532 1.5 72.7 1.0
O2B B:ANP532 1.5 73.4 1.0
O3A B:ANP532 1.6 66.9 1.0
N3B B:ANP532 1.6 78.8 1.0
PG B:ANP532 2.9 86.5 1.0
PA B:ANP532 3.0 59.9 1.0
O3G B:ANP532 3.1 84.2 1.0
CA B:CA4 3.4 30.2 1.0
O2A B:ANP532 3.6 62.1 1.0
O1G B:ANP532 3.6 86.8 1.0
O1A B:ANP532 3.6 58.1 1.0
HH22 B:ARG388 3.6 0.0 1.0
HD21 B:ASN391 3.9 0.0 1.0
O5' B:ANP532 3.9 54.6 1.0
HZ3 B:LYS295 3.9 0.0 1.0
O2G B:ANP532 4.0 86.5 1.0
C5' B:ANP532 4.3 48.0 1.0
NH2 B:ARG388 4.3 35.1 1.0
HH21 B:ARG388 4.5 0.0 1.0
ND2 B:ASN391 4.6 29.6 1.0
HD22 B:ASN391 4.6 0.0 1.0
NZ B:LYS295 4.9 34.2 1.0

Phosphorus binding site 8 out of 8 in 1ad5

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Phosphorus binding site 8 out of 8 in the Src Family Kinase Hck-Amp-Pnp Complex


Mono view


Stereo pair view

A full contact list of Phosphorus with other atoms in the P binding site number 8 of Src Family Kinase Hck-Amp-Pnp Complex within 5.0Å range:
probe atom residue distance (Å) B Occ
B:P532

b:59.9
occ:1.00
 PA B:ANP532 0.0 59.9 1.0
O2A B:ANP532 1.5 62.1 1.0
O1A B:ANP532 1.5 58.1 1.0
O5' B:ANP532 1.6 54.6 1.0
O3A B:ANP532 1.6 66.9 1.0
C5' B:ANP532 2.6 48.0 1.0
PB B:ANP532 3.0 72.5 1.0
O2B B:ANP532 3.5 73.4 1.0
HZ3 B:LYS295 3.5 0.0 1.0
O1B B:ANP532 3.6 72.7 1.0
CA B:CA4 3.7 30.2 1.0
C4' B:ANP532 3.8 44.5 1.0
CG2 B:VAL281 3.9 20.6 1.0
HZ2 B:LYS295 4.0 0.0 1.0
O3G B:ANP532 4.0 84.2 1.0
N3B B:ANP532 4.0 78.8 1.0
CE B:LYS295 4.0 29.6 1.0
NZ B:LYS295 4.0 34.2 1.0
O4' B:ANP532 4.1 40.8 1.0
O1G B:ANP532 4.4 86.8 1.0
PG B:ANP532 4.4 86.5 1.0
H B:GLY276 4.8 0.0 1.0
C8 B:ANP532 4.8 33.3 1.0

Reference:

F.Sicheri, I.Moarefi, J.Kuriyan. Crystal Structure of the Src Family Tyrosine Kinase Hck. Nature V. 385 602 1997.
ISSN: ISSN 0028-0836
PubMed: 9024658
DOI: 10.1038/385602A0
Page generated: Fri Sep 25 12:45:21 2020

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