Phosphorus in PDB 1ad4: Dihydropteroate Synthetase Complexed with Oh-CH2-Pterin- Pyrophosphate From Staphylococcus Aureus

All present enzymatic activity of Dihydropteroate Synthetase Complexed with Oh-CH2-Pterin- Pyrophosphate From Staphylococcus Aureus:
2.5.1.15;

The structure of Dihydropteroate Synthetase Complexed with Oh-CH2-Pterin- Pyrophosphate From Staphylococcus Aureus, PDB code: 1ad4 was solved by C.Oefner, D.Kostrewa, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	13.00 / 2.40
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	65.748, 42.142, 99.040, 90.00, 106.06, 90.00
R / Rfree (%)	17.6 / n/a

The binding sites of Phosphorus atom in the Dihydropteroate Synthetase Complexed with Oh-CH2-Pterin- Pyrophosphate From Staphylococcus Aureus (pdb code 1ad4). This binding sites where shown within 5.0 Angstroms radius around Phosphorus atom.
In total 2 binding sites of Phosphorus where determined in the Dihydropteroate Synthetase Complexed with Oh-CH2-Pterin- Pyrophosphate From Staphylococcus Aureus, PDB code: 1ad4:
Jump to Phosphorus binding site number: 1; 2;

Phosphorus binding site 1 out of 2 in the Dihydropteroate Synthetase Complexed with Oh-CH2-Pterin- Pyrophosphate From Staphylococcus Aureus


Mono view


Stereo pair view

A full contact list of Phosphorus with other atoms in the P binding site number 1 of Dihydropteroate Synthetase Complexed with Oh-CH2-Pterin- Pyrophosphate From Staphylococcus Aureus within 5.0Å range: probe atom residue distance (Å) B Occ A:P271 b:15.1 occ:1.00 P1 A:HH2271 0.0 15.1 1.0 O1P A:HH2271 1.5 16.1 1.0 O2P A:HH2271 1.5 14.8 1.0 O3P A:HH2271 1.6 14.1 1.0 O4 A:HH2271 1.6 11.7 1.0 C11 A:HH2271 2.7 19.4 1.0 P2 A:HH2271 3.0 18.1 1.0 O6P A:HH2271 3.2 16.8 1.0 O4P A:HH2271 3.6 11.1 1.0 O A:HOH362 3.6 29.3 1.0 O A:HOH336 3.7 21.9 1.0 C2 A:HH2271 3.9 12.5 1.0 O5P A:HH2271 4.0 1.1 1.0 NE A:ARG52 4.2 34.9 1.0 MN A:MN269 4.2 37.7 1.0 C3 A:HH2271 4.3 14.6 1.0 CD A:ARG52 4.9 28.5 1.0 NH2 A:ARG52 4.9 33.7 1.0 OG A:SER50 4.9 33.3 1.0 CZ A:ARG52 5.0 33.5 1.0

Phosphorus binding site 2 out of 2 in the Dihydropteroate Synthetase Complexed with Oh-CH2-Pterin- Pyrophosphate From Staphylococcus Aureus


Mono view


Stereo pair view

A full contact list of Phosphorus with other atoms in the P binding site number 2 of Dihydropteroate Synthetase Complexed with Oh-CH2-Pterin- Pyrophosphate From Staphylococcus Aureus within 5.0Å range: probe atom residue distance (Å) B Occ A:P271 b:18.1 occ:1.00 P2 A:HH2271 0.0 18.1 1.0 O4P A:HH2271 1.5 11.1 1.0 O6P A:HH2271 1.5 16.8 1.0 O5P A:HH2271 1.5 1.1 1.0 O3P A:HH2271 1.6 14.1 1.0 P1 A:HH2271 3.0 15.1 1.0 O4 A:HH2271 3.3 11.7 1.0 MN A:MN269 3.5 37.7 1.0 O2P A:HH2271 3.5 14.8 1.0 C11 A:HH2271 3.7 19.4 1.0 NH1 A:ARG239 4.1 10.7 1.0 NE2 A:HIS241 4.1 11.0 1.0 NH2 A:ARG239 4.1 9.9 1.0 O1P A:HH2271 4.1 16.1 1.0 O A:HOH336 4.1 21.9 1.0 O A:HOH325 4.2 12.0 1.0 C2 A:HH2271 4.2 12.5 1.0 OD1 A:ASN11 4.2 34.0 1.0 ND2 A:ASN11 4.3 26.4 1.0 CE1 A:HIS241 4.3 9.4 1.0 C3 A:HH2271 4.4 14.6 1.0 O A:HOH362 4.4 29.3 1.0 CZ A:ARG239 4.6 2.0 1.0 CG2 A:ILE9 4.6 6.3 1.0 CD1 A:ILE9 4.7 2.0 1.0 CG A:ASN11 4.7 28.4 1.0

I.C.Hampele, A.D'arcy, G.E.Dale, D.Kostrewa, J.Nielsen, C.Oefner, M.G.Page, H.J.Schonfeld, D.Stuber, R.L.Then. Structure and Function of the Dihydropteroate Synthase From Staphylococcus Aureus. J.Mol.Biol. V. 268 21 1997.
ISSN: ISSN 0022-2836
PubMed: 9149138
DOI: 10.1006/JMBI.1997.0944