Phosphorus in PDB 1a8n: Solution Structure of A Na+ Cation Stabilized Dna Quadruplex Containing G.G.G.G and G.C.G.C Tetrads Formed By G-G-G-C Repeats Observed in Aav and Human Chromosome 19, uc(Nmr), 8 Structures

Pages:

>>> Page 1 <<< Page 2, Binding sites: 11 - 20; Page 3, Binding sites: 21 - 22;

Binding sites:

The binding sites of Phosphorus atom in the Solution Structure of A Na+ Cation Stabilized Dna Quadruplex Containing G.G.G.G and G.C.G.C Tetrads Formed By G-G-G-C Repeats Observed in Aav and Human Chromosome 19, uc(Nmr), 8 Structures (pdb code 1a8n). This binding sites where shown within 5.0 Angstroms radius around Phosphorus atom.
In total 22 binding sites of Phosphorus where determined in the Solution Structure of A Na+ Cation Stabilized Dna Quadruplex Containing G.G.G.G and G.C.G.C Tetrads Formed By G-G-G-C Repeats Observed in Aav and Human Chromosome 19, uc(Nmr), 8 Structures, PDB code: 1a8n:
Jump to Phosphorus binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;

Phosphorus binding site 1 out of 22 in the Solution Structure of A Na+ Cation Stabilized Dna Quadruplex Containing G.G.G.G and G.C.G.C Tetrads Formed By G-G-G-C Repeats Observed in Aav and Human Chromosome 19, uc(Nmr), 8 Structures


Mono view


Stereo pair view

A full contact list of Phosphorus with other atoms in the P binding site number 1 of Solution Structure of A Na+ Cation Stabilized Dna Quadruplex Containing G.G.G.G and G.C.G.C Tetrads Formed By G-G-G-C Repeats Observed in Aav and Human Chromosome 19, uc(Nmr), 8 Structures within 5.0Å range: probe atom residue distance (Å) B Occ A:P2 b:0.8 occ:1.00 P A:DG2 0.0 0.8 1.0 OP2 A:DG2 1.5 1.0 1.0 OP1 A:DG2 1.5 1.2 1.0 O3' A:DG1 1.6 0.8 1.0 O5' A:DG2 1.6 0.6 1.0 H3' A:DG2 2.5 0.8 1.0 C3' A:DG1 2.7 0.6 1.0 C5' A:DG2 2.8 0.6 1.0 H2'' A:DG1 2.8 0.5 1.0 H4' A:DG1 2.9 0.7 1.0 H5'' A:DG2 3.0 0.8 1.0 C2' A:DG1 3.2 0.5 1.0 C4' A:DG1 3.4 0.7 1.0 C3' A:DG2 3.4 0.7 1.0 C4' A:DG2 3.5 0.5 1.0 H3' A:DG1 3.6 0.7 1.0 H5' A:DG2 3.6 0.7 1.0 OP2 B:DG2 3.8 1.0 1.0 H5' A:DG1 3.9 1.1 1.0 H2' A:DG2 3.9 0.7 1.0 H2' A:DG1 4.0 0.5 1.0 O4' A:DG2 4.1 0.5 1.0 H1' A:DG1 4.2 0.6 1.0 C1' A:DG1 4.2 0.5 1.0 H22 A:DG2 4.3 0.4 1.0 C2' A:DG2 4.3 0.6 1.0 C5' A:DG1 4.3 1.0 1.0 O3' A:DG2 4.3 1.0 1.0 H4' A:DG2 4.5 0.7 1.0 O4' A:DG1 4.5 0.6 1.0 P B:DG2 4.7 0.8 1.0 N3 A:DG2 4.8 0.3 1.0 O3' B:DG1 4.9 0.8 1.0 H5'' A:DG1 4.9 1.0 1.0 C1' A:DG2 5.0 0.5 1.0 H3' B:DG2 5.0 0.8 1.0

Phosphorus binding site 2 out of 22 in the Solution Structure of A Na+ Cation Stabilized Dna Quadruplex Containing G.G.G.G and G.C.G.C Tetrads Formed By G-G-G-C Repeats Observed in Aav and Human Chromosome 19, uc(Nmr), 8 Structures


Mono view


Stereo pair view

A full contact list of Phosphorus with other atoms in the P binding site number 2 of Solution Structure of A Na+ Cation Stabilized Dna Quadruplex Containing G.G.G.G and G.C.G.C Tetrads Formed By G-G-G-C Repeats Observed in Aav and Human Chromosome 19, uc(Nmr), 8 Structures within 5.0Å range: probe atom residue distance (Å) B Occ A:P3 b:1.1 occ:1.00 P A:DG3 0.0 1.1 1.0 OP2 A:DG3 1.5 1.7 1.0 OP1 A:DG3 1.5 1.3 1.0 O3' A:DG2 1.6 1.0 1.0 O5' A:DG3 1.6 0.9 1.0 C5' A:DG3 2.6 0.8 1.0 C3' A:DG2 2.7 0.7 1.0 H5'' A:DG3 2.9 0.9 1.0 H2'' A:DG2 2.9 0.7 1.0 H5' A:DG3 2.9 0.9 1.0 H4' A:DG2 3.0 0.7 1.0 H1' A:DG2 3.1 0.6 1.0 C2' A:DG2 3.2 0.6 1.0 C4' A:DG2 3.3 0.5 1.0 H3' A:DG2 3.6 0.8 1.0 C1' A:DG2 3.7 0.5 1.0 C4' A:DG3 4.0 0.6 1.0 O4' A:DG2 4.2 0.5 1.0 H3' A:DG3 4.2 0.6 1.0 H5'' A:DG2 4.2 0.8 1.0 H2' A:DG2 4.2 0.7 1.0 O4' A:DG3 4.4 0.5 1.0 C5' A:DG2 4.4 0.6 1.0 C3' A:DG3 4.7 0.5 1.0 H4' A:DG3 4.8 0.8 1.0 H2' A:DG3 4.8 0.6 1.0 N9 A:DG2 5.0 0.4 1.0

Phosphorus binding site 3 out of 22 in the Solution Structure of A Na+ Cation Stabilized Dna Quadruplex Containing G.G.G.G and G.C.G.C Tetrads Formed By G-G-G-C Repeats Observed in Aav and Human Chromosome 19, uc(Nmr), 8 Structures


Mono view


Stereo pair view

A full contact list of Phosphorus with other atoms in the P binding site number 3 of Solution Structure of A Na+ Cation Stabilized Dna Quadruplex Containing G.G.G.G and G.C.G.C Tetrads Formed By G-G-G-C Repeats Observed in Aav and Human Chromosome 19, uc(Nmr), 8 Structures within 5.0Å range: probe atom residue distance (Å) B Occ A:P4 b:1.0 occ:1.00 P A:DC4 0.0 1.0 1.0 OP2 A:DC4 1.5 1.1 1.0 OP1 A:DC4 1.5 1.2 1.0 O3' A:DG3 1.6 0.7 1.0 O5' A:DC4 1.6 1.2 1.0 C5' A:DC4 2.7 1.0 1.0 H2'' A:DG3 2.7 0.6 1.0 H5'' A:DC4 2.7 1.1 1.0 C3' A:DG3 2.7 0.5 1.0 H3' A:DC4 3.0 0.7 1.0 C2' A:DG3 3.1 0.5 1.0 H1' A:DG3 3.3 0.6 1.0 H3' A:DG3 3.4 0.6 1.0 H72 A:DT5 3.4 1.2 1.0 H5' A:DC4 3.5 1.1 1.0 C3' A:DC4 3.5 0.6 1.0 C4' A:DC4 3.6 0.7 1.0 H4' A:DG3 3.7 0.8 1.0 C1' A:DG3 3.7 0.5 1.0 O3' A:DC4 3.7 0.7 1.0 C4' A:DG3 3.9 0.6 1.0 H2' A:DG3 4.0 0.6 1.0 H6 A:DC4 4.2 0.7 1.0 O4' A:DC4 4.3 0.7 1.0 C7 A:DT5 4.3 1.2 1.0 H4' A:DC4 4.4 0.7 1.0 OP1 A:DT5 4.4 0.9 1.0 H73 A:DT5 4.4 1.3 1.0 O4' A:DG3 4.4 0.5 1.0 P A:DT5 4.6 0.8 1.0 C5 A:DT5 4.9 1.0 1.0 N9 A:DG3 4.9 0.4 1.0

Phosphorus binding site 4 out of 22 in the Solution Structure of A Na+ Cation Stabilized Dna Quadruplex Containing G.G.G.G and G.C.G.C Tetrads Formed By G-G-G-C Repeats Observed in Aav and Human Chromosome 19, uc(Nmr), 8 Structures


Mono view


Stereo pair view

A full contact list of Phosphorus with other atoms in the P binding site number 4 of Solution Structure of A Na+ Cation Stabilized Dna Quadruplex Containing G.G.G.G and G.C.G.C Tetrads Formed By G-G-G-C Repeats Observed in Aav and Human Chromosome 19, uc(Nmr), 8 Structures within 5.0Å range: probe atom residue distance (Å) B Occ A:P5 b:0.8 occ:1.00 P A:DT5 0.0 0.8 1.0 OP1 A:DT5 1.5 0.9 1.0 OP2 A:DT5 1.5 1.0 1.0 O3' A:DC4 1.6 0.7 1.0 O5' A:DT5 1.6 0.7 1.0 C5' A:DT5 2.7 0.7 1.0 C3' A:DC4 2.7 0.6 1.0 H5'' A:DT5 2.8 0.9 1.0 H4' A:DC4 3.0 0.7 1.0 H2'' A:DC4 3.2 0.5 1.0 H5'' A:DC4 3.3 1.1 1.0 C4' A:DC4 3.3 0.7 1.0 O4' A:DT5 3.3 0.6 1.0 C2' A:DC4 3.5 0.5 1.0 H5' A:DT5 3.5 0.8 1.0 H3' A:DC4 3.6 0.7 1.0 C4' A:DT5 3.7 0.6 1.0 H6 A:DT5 3.8 0.8 1.0 C5' A:DC4 3.8 1.0 1.0 OP1 A:DC4 4.1 1.2 1.0 H2' A:DC4 4.1 0.5 1.0 H4' A:DT5 4.2 0.5 1.0 H72 A:DT5 4.3 1.2 1.0 C6 A:DT5 4.4 0.8 1.0 O4' A:DC4 4.6 0.7 1.0 O5' A:DC4 4.6 1.2 1.0 P A:DC4 4.6 1.0 1.0 C1' A:DT5 4.7 0.6 1.0 H5' A:DC4 4.7 1.1 1.0 C1' A:DC4 4.7 0.5 1.0 OP2 A:DC4 4.7 1.1 1.0 N1 A:DT5 4.8 0.8 1.0 C3' A:DT5 4.9 0.6 1.0 H3' A:DT5 4.9 0.8 1.0 H2' A:DT5 5.0 0.8 1.0

Phosphorus binding site 5 out of 22 in the Solution Structure of A Na+ Cation Stabilized Dna Quadruplex Containing G.G.G.G and G.C.G.C Tetrads Formed By G-G-G-C Repeats Observed in Aav and Human Chromosome 19, uc(Nmr), 8 Structures


Mono view


Stereo pair view

A full contact list of Phosphorus with other atoms in the P binding site number 5 of Solution Structure of A Na+ Cation Stabilized Dna Quadruplex Containing G.G.G.G and G.C.G.C Tetrads Formed By G-G-G-C Repeats Observed in Aav and Human Chromosome 19, uc(Nmr), 8 Structures within 5.0Å range: probe atom residue distance (Å) B Occ A:P6 b:0.6 occ:1.00 P A:DT6 0.0 0.6 1.0 OP2 A:DT6 1.5 0.7 1.0 OP1 A:DT6 1.5 0.6 1.0 O5' A:DT6 1.6 0.7 1.0 O3' A:DT5 1.6 0.6 1.0 H3' A:DT6 2.7 1.0 1.0 C3' A:DT5 2.8 0.6 1.0 C5' A:DT6 2.8 0.7 1.0 H4' A:DT5 2.9 0.5 1.0 H6 A:DT6 3.0 1.1 1.0 H1' A:DT5 3.0 0.6 1.0 H5'' A:DT6 3.2 0.9 1.0 H2'' A:DT5 3.3 0.7 1.0 C4' A:DT6 3.4 0.7 1.0 C4' A:DT5 3.4 0.6 1.0 O4' A:DT6 3.4 0.8 1.0 C2' A:DT5 3.5 0.7 1.0 C3' A:DT6 3.5 0.9 1.0 H5' A:DT6 3.6 0.8 1.0 H3' A:DT5 3.6 0.8 1.0 C1' A:DT5 3.7 0.6 1.0 C6 A:DT6 3.9 1.2 1.0 O4' A:DT5 4.1 0.6 1.0 OP1 A:DT7 4.2 1.6 1.0 C1' A:DT6 4.2 1.0 1.0 H71 A:DT6 4.3 1.6 1.0 C2' A:DT6 4.4 1.1 1.0 H4' A:DT6 4.4 0.8 1.0 H2' A:DT5 4.5 0.8 1.0 N1 A:DT6 4.5 1.1 1.0 H2' A:DT6 4.5 1.2 1.0 H73 A:DT6 4.6 1.9 1.0 O3' A:DT6 4.7 1.2 1.0 H5' A:DT5 4.7 0.8 1.0 C5' A:DT5 4.7 0.7 1.0 C5 A:DT6 4.8 1.4 1.0 C7 A:DT6 4.8 1.5 1.0 O2 A:DT5 5.0 0.9 1.0

Phosphorus binding site 6 out of 22 in the Solution Structure of A Na+ Cation Stabilized Dna Quadruplex Containing G.G.G.G and G.C.G.C Tetrads Formed By G-G-G-C Repeats Observed in Aav and Human Chromosome 19, uc(Nmr), 8 Structures


Mono view


Stereo pair view

A full contact list of Phosphorus with other atoms in the P binding site number 6 of Solution Structure of A Na+ Cation Stabilized Dna Quadruplex Containing G.G.G.G and G.C.G.C Tetrads Formed By G-G-G-C Repeats Observed in Aav and Human Chromosome 19, uc(Nmr), 8 Structures within 5.0Å range: probe atom residue distance (Å) B Occ A:P7 b:1.4 occ:1.00 P A:DT7 0.0 1.4 1.0 OP2 A:DT7 1.5 1.9 1.0 OP1 A:DT7 1.5 1.6 1.0 O5' A:DT7 1.6 1.3 1.0 O3' A:DT6 1.6 1.2 1.0 C3' A:DT6 2.6 0.9 1.0 C5' A:DT7 2.6 1.1 1.0 H3' A:DT6 2.8 1.0 1.0 H5'' A:DT7 2.9 0.9 1.0 H5' A:DT7 2.9 1.3 1.0 H5'' A:DT6 3.1 0.9 1.0 H4' A:DT6 3.3 0.8 1.0 C4' A:DT6 3.3 0.7 1.0 H2'' A:DT6 3.7 1.1 1.0 C5' A:DT6 3.8 0.7 1.0 C2' A:DT6 3.8 1.1 1.0 C4' A:DT7 3.9 1.1 1.0 H4' A:DT7 4.1 1.4 1.0 OP2 A:DT6 4.1 0.7 1.0 O4' A:DT7 4.2 1.1 1.0 H2' A:DT6 4.3 1.2 1.0 H5' A:DT6 4.5 0.8 1.0 O4' A:DT6 4.6 0.8 1.0 O5' A:DT6 4.7 0.7 1.0 C1' A:DT6 4.9 1.0 1.0

Phosphorus binding site 7 out of 22 in the Solution Structure of A Na+ Cation Stabilized Dna Quadruplex Containing G.G.G.G and G.C.G.C Tetrads Formed By G-G-G-C Repeats Observed in Aav and Human Chromosome 19, uc(Nmr), 8 Structures


Mono view


Stereo pair view

A full contact list of Phosphorus with other atoms in the P binding site number 7 of Solution Structure of A Na+ Cation Stabilized Dna Quadruplex Containing G.G.G.G and G.C.G.C Tetrads Formed By G-G-G-C Repeats Observed in Aav and Human Chromosome 19, uc(Nmr), 8 Structures within 5.0Å range: probe atom residue distance (Å) B Occ A:P8 b:1.1 occ:1.00 P A:DT8 0.0 1.1 1.0 OP2 A:DT8 1.5 1.1 1.0 OP1 A:DT8 1.5 1.2 1.0 O3' A:DT7 1.6 1.4 1.0 O5' A:DT8 1.6 1.2 1.0 H5'' A:DT8 2.6 1.1 1.0 C5' A:DT8 2.6 1.1 1.0 C3' A:DT7 2.6 1.2 1.0 H3' A:DT7 2.9 1.2 1.0 H4' A:DT7 3.1 1.4 1.0 O4' A:DT8 3.4 0.8 1.0 C4' A:DT7 3.4 1.1 1.0 H5' A:DT8 3.4 1.3 1.0 H2'' A:DT7 3.6 1.1 1.0 C4' A:DT8 3.6 0.9 1.0 H6 A:DT8 3.7 0.7 1.0 C2' A:DT7 3.8 1.2 1.0 H5' A:DT7 3.8 1.3 1.0 H2' A:DT8 4.1 0.9 1.0 C6 A:DT8 4.1 0.7 1.0 H4' A:DT8 4.2 0.9 1.0 C5' A:DT7 4.2 1.1 1.0 H2' A:DT7 4.3 1.4 1.0 H72 A:DT8 4.4 1.3 1.0 C1' A:DT8 4.4 0.7 1.0 N1 A:DT8 4.5 0.8 1.0 O4' A:DT7 4.6 1.1 1.0 C2' A:DT8 4.7 0.9 1.0 C1' A:DT7 4.7 1.1 1.0 C3' A:DT8 4.8 0.9 1.0 C5 A:DT8 4.8 0.9 1.0 H5'' A:DT7 4.9 0.9 1.0

Phosphorus binding site 8 out of 22 in the Solution Structure of A Na+ Cation Stabilized Dna Quadruplex Containing G.G.G.G and G.C.G.C Tetrads Formed By G-G-G-C Repeats Observed in Aav and Human Chromosome 19, uc(Nmr), 8 Structures


Mono view


Stereo pair view

A full contact list of Phosphorus with other atoms in the P binding site number 8 of Solution Structure of A Na+ Cation Stabilized Dna Quadruplex Containing G.G.G.G and G.C.G.C Tetrads Formed By G-G-G-C Repeats Observed in Aav and Human Chromosome 19, uc(Nmr), 8 Structures within 5.0Å range: probe atom residue distance (Å) B Occ A:P9 b:0.8 occ:1.00 P A:DG9 0.0 0.8 1.0 OP2 A:DG9 1.5 0.8 1.0 OP1 A:DG9 1.5 1.1 1.0 O3' A:DT8 1.6 0.8 1.0 O5' A:DG9 1.6 0.7 1.0 C3' A:DT8 2.7 0.9 1.0 C5' A:DG9 2.7 0.8 1.0 H5' A:DG9 2.8 0.9 1.0 H3' A:DT8 2.8 1.1 1.0 H8 A:DG9 2.9 0.5 1.0 H5'' A:DG9 3.2 0.9 1.0 H2'' A:DT8 3.3 0.9 1.0 H2' B:DG11 3.4 0.8 1.0 C2' A:DT8 3.5 0.9 1.0 H1' A:DT8 3.6 0.8 1.0 H2' A:DG9 3.7 0.5 1.0 C8 A:DG9 3.9 0.4 1.0 H5 B:DC12 3.9 0.5 1.0 H2'' B:DG11 3.9 0.8 1.0 C4' A:DG9 4.0 0.6 1.0 H4' A:DT8 4.0 0.9 1.0 C4' A:DT8 4.0 0.9 1.0 C1' A:DT8 4.1 0.7 1.0 O4' A:DG9 4.2 0.6 1.0 C2' B:DG11 4.2 0.8 1.0 H8 B:DG11 4.3 0.7 1.0 H6 B:DC12 4.3 0.7 1.0 H2' A:DT8 4.4 0.9 1.0 C2' A:DG9 4.5 0.4 1.0 O4' A:DT8 4.6 0.8 1.0 N9 A:DG9 4.6 0.4 1.0 C8 B:DG11 4.7 0.6 1.0 N7 A:DG9 4.7 0.4 1.0 C1' A:DG9 4.7 0.4 1.0 H3' A:DG9 4.8 0.6 1.0 H5'' B:DG11 4.8 0.8 1.0 H4' A:DG9 4.8 0.7 1.0 C3' A:DG9 4.8 0.5 1.0 C5 B:DC12 4.8 0.5 1.0

Phosphorus binding site 9 out of 22 in the Solution Structure of A Na+ Cation Stabilized Dna Quadruplex Containing G.G.G.G and G.C.G.C Tetrads Formed By G-G-G-C Repeats Observed in Aav and Human Chromosome 19, uc(Nmr), 8 Structures


Mono view


Stereo pair view

A full contact list of Phosphorus with other atoms in the P binding site number 9 of Solution Structure of A Na+ Cation Stabilized Dna Quadruplex Containing G.G.G.G and G.C.G.C Tetrads Formed By G-G-G-C Repeats Observed in Aav and Human Chromosome 19, uc(Nmr), 8 Structures within 5.0Å range: probe atom residue distance (Å) B Occ A:P10 b:0.8 occ:1.00 P A:DG10 0.0 0.8 1.0 OP2 A:DG10 1.5 1.0 1.0 OP1 A:DG10 1.5 1.0 1.0 O3' A:DG9 1.6 0.6 1.0 O5' A:DG10 1.6 0.8 1.0 C3' A:DG9 2.7 0.5 1.0 C5' A:DG10 2.7 0.6 1.0 H5'' A:DG10 2.8 0.7 1.0 H3' A:DG9 2.8 0.6 1.0 H2'' A:DG9 3.1 0.6 1.0 H5' A:DG10 3.1 0.7 1.0 C2' A:DG9 3.4 0.4 1.0 H1' A:DG9 3.9 0.6 1.0 C4' A:DG10 4.1 0.6 1.0 C4' A:DG9 4.1 0.6 1.0 H4' A:DG9 4.1 0.7 1.0 C1' A:DG9 4.2 0.4 1.0 H2' A:DG9 4.2 0.5 1.0 H4' A:DG10 4.2 0.7 1.0 H3' A:DG10 4.5 0.7 1.0 O4' A:DG9 4.7 0.6 1.0 C3' A:DG10 4.9 0.7 1.0 H22 A:DG10 5.0 0.4 1.0

Phosphorus binding site 10 out of 22 in the Solution Structure of A Na+ Cation Stabilized Dna Quadruplex Containing G.G.G.G and G.C.G.C Tetrads Formed By G-G-G-C Repeats Observed in Aav and Human Chromosome 19, uc(Nmr), 8 Structures


Mono view


Stereo pair view

A full contact list of Phosphorus with other atoms in the P binding site number 10 of Solution Structure of A Na+ Cation Stabilized Dna Quadruplex Containing G.G.G.G and G.C.G.C Tetrads Formed By G-G-G-C Repeats Observed in Aav and Human Chromosome 19, uc(Nmr), 8 Structures within 5.0Å range: probe atom residue distance (Å) B Occ A:P11 b:0.9 occ:1.00 P A:DG11 0.0 0.9 1.0 OP1 A:DG11 1.5 1.2 1.0 OP2 A:DG11 1.5 1.1 1.0 O3' A:DG10 1.6 0.8 1.0 O5' A:DG11 1.6 0.8 1.0 C5' A:DG11 2.7 0.8 1.0 C3' A:DG10 2.7 0.7 1.0 H5' A:DG11 2.9 1.0 1.0 H2'' A:DG10 2.9 0.7 1.0 H3' A:DG10 3.0 0.7 1.0 H5'' A:DG11 3.0 0.8 1.0 H1' A:DG10 3.1 0.7 1.0 C2' A:DG10 3.2 0.6 1.0 C1' A:DG10 3.7 0.6 1.0 C4' A:DG10 4.0 0.6 1.0 C4' A:DG11 4.0 0.8 1.0 H4' A:DG10 4.0 0.7 1.0 H4' A:DG11 4.2 0.9 1.0 H2' A:DG10 4.2 0.6 1.0 O4' A:DG10 4.4 0.6 1.0 O4' A:DG11 4.5 0.8 1.0 N9 A:DG10 4.9 0.5 1.0 H8 A:DG11 4.9 0.7 1.0

A.Kettani, S.Bouaziz, A.Gorin, H.Zhao, R.A.Jones, D.J.Patel. Solution Structure of A Na Cation Stabilized Dna Quadruplex Containing G.G.G.G and G.C.G.C Tetrads Formed By G-G-G-C Repeats Observed in Adeno-Associated Viral Dna. J.Mol.Biol. V. 282 619 1998.
ISSN: ISSN 0022-2836
PubMed: 9737926
DOI: 10.1006/JMBI.1998.2030