Phosphorus in PDB 1a84: uc(Nmr) Solution Structure of A Dna Dodecamer Duplex Containing A Cis- Diammineplatinum(II) D(Gpg) Intrastrand Cross-Link, the Major Adduct of the Anticancer Drug Cisplatin, 1 Structure

Pages:

>>> Page 1 <<< Page 2, Binding sites: 11 - 20; Page 3, Binding sites: 21 - 22;

Binding sites:

The binding sites of Phosphorus atom in the uc(Nmr) Solution Structure of A Dna Dodecamer Duplex Containing A Cis- Diammineplatinum(II) D(Gpg) Intrastrand Cross-Link, the Major Adduct of the Anticancer Drug Cisplatin, 1 Structure (pdb code 1a84). This binding sites where shown within 5.0 Angstroms radius around Phosphorus atom.
In total 22 binding sites of Phosphorus where determined in the uc(Nmr) Solution Structure of A Dna Dodecamer Duplex Containing A Cis- Diammineplatinum(II) D(Gpg) Intrastrand Cross-Link, the Major Adduct of the Anticancer Drug Cisplatin, 1 Structure, PDB code: 1a84:
Jump to Phosphorus binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;

Phosphorus binding site 1 out of 22 in the uc(Nmr) Solution Structure of A Dna Dodecamer Duplex Containing A Cis- Diammineplatinum(II) D(Gpg) Intrastrand Cross-Link, the Major Adduct of the Anticancer Drug Cisplatin, 1 Structure


Mono view


Stereo pair view

A full contact list of Phosphorus with other atoms in the P binding site number 1 of uc(Nmr) Solution Structure of A Dna Dodecamer Duplex Containing A Cis- Diammineplatinum(II) D(Gpg) Intrastrand Cross-Link, the Major Adduct of the Anticancer Drug Cisplatin, 1 Structure within 5.0Å range: probe atom residue distance (Å) B Occ A:P2 b:0.0 occ:1.00 P A:DC2 0.0 0.0 1.0 OP2 A:DC2 1.5 0.0 1.0 OP1 A:DC2 1.5 0.0 1.0 O5' A:DC2 1.6 0.0 1.0 O3' A:DC1 1.6 0.0 1.0 C5' A:DC2 2.6 0.0 1.0 C3' A:DC1 2.6 0.0 1.0 H3' A:DC1 2.8 0.0 1.0 H5' A:DC2 2.8 0.0 1.0 H5'' A:DC2 2.9 0.0 1.0 H2'' A:DC1 3.0 0.0 1.0 HO5' A:DC1 3.2 0.0 1.0 C2' A:DC1 3.3 0.0 1.0 H6 A:DC2 3.5 0.0 1.0 H2' A:DC1 3.6 0.0 1.0 C4' A:DC1 3.9 0.0 1.0 C4' A:DC2 3.9 0.0 1.0 H4' A:DC1 4.0 0.0 1.0 O5' A:DC1 4.1 0.0 1.0 H3' A:DC2 4.2 0.0 1.0 O4' A:DC2 4.3 0.0 1.0 H2' A:DC2 4.4 0.0 1.0 C6 A:DC2 4.5 0.0 1.0 C3' A:DC2 4.6 0.0 1.0 C1' A:DC1 4.6 0.0 1.0 C5' A:DC1 4.7 0.0 1.0 H4' A:DC2 4.8 0.0 1.0 O4' A:DC1 4.9 0.0 1.0 H1' A:DC1 4.9 0.0 1.0 C2' A:DC2 4.9 0.0 1.0

Phosphorus binding site 2 out of 22 in the uc(Nmr) Solution Structure of A Dna Dodecamer Duplex Containing A Cis- Diammineplatinum(II) D(Gpg) Intrastrand Cross-Link, the Major Adduct of the Anticancer Drug Cisplatin, 1 Structure


Mono view


Stereo pair view

A full contact list of Phosphorus with other atoms in the P binding site number 2 of uc(Nmr) Solution Structure of A Dna Dodecamer Duplex Containing A Cis- Diammineplatinum(II) D(Gpg) Intrastrand Cross-Link, the Major Adduct of the Anticancer Drug Cisplatin, 1 Structure within 5.0Å range: probe atom residue distance (Å) B Occ A:P3 b:0.0 occ:1.00 P A:DT3 0.0 0.0 1.0 OP2 A:DT3 1.5 0.0 1.0 OP1 A:DT3 1.5 0.0 1.0 O5' A:DT3 1.6 0.0 1.0 O3' A:DC2 1.6 0.0 1.0 H5' A:DT3 2.6 0.0 1.0 C5' A:DT3 2.6 0.0 1.0 H2'' A:DC2 2.6 0.0 1.0 C3' A:DC2 2.7 0.0 1.0 H3' A:DC2 2.9 0.0 1.0 H3' A:DT3 3.0 0.0 1.0 C2' A:DC2 3.1 0.0 1.0 H5'' A:DT3 3.3 0.0 1.0 C4' A:DT3 3.7 0.0 1.0 C3' A:DT3 3.8 0.0 1.0 H2' A:DT3 3.8 0.0 1.0 H2' A:DC2 3.9 0.0 1.0 C4' A:DC2 4.0 0.0 1.0 H1' A:DC2 4.0 0.0 1.0 H4' A:DC2 4.0 0.0 1.0 C1' A:DC2 4.1 0.0 1.0 H6 A:DT3 4.3 0.0 1.0 C2' A:DT3 4.4 0.0 1.0 H4' A:DT3 4.5 0.0 1.0 O4' A:DT3 4.5 0.0 1.0 O4' A:DC2 4.7 0.0 1.0

Phosphorus binding site 3 out of 22 in the uc(Nmr) Solution Structure of A Dna Dodecamer Duplex Containing A Cis- Diammineplatinum(II) D(Gpg) Intrastrand Cross-Link, the Major Adduct of the Anticancer Drug Cisplatin, 1 Structure


Mono view


Stereo pair view

A full contact list of Phosphorus with other atoms in the P binding site number 3 of uc(Nmr) Solution Structure of A Dna Dodecamer Duplex Containing A Cis- Diammineplatinum(II) D(Gpg) Intrastrand Cross-Link, the Major Adduct of the Anticancer Drug Cisplatin, 1 Structure within 5.0Å range: probe atom residue distance (Å) B Occ A:P4 b:0.0 occ:1.00 P A:DC4 0.0 0.0 1.0 OP2 A:DC4 1.5 0.0 1.0 OP1 A:DC4 1.5 0.0 1.0 O3' A:DT3 1.6 0.0 1.0 O5' A:DC4 1.6 0.0 1.0 H2'' A:DT3 2.6 0.0 1.0 C3' A:DT3 2.6 0.0 1.0 C5' A:DC4 2.7 0.0 1.0 H5' A:DC4 2.7 0.0 1.0 H3' A:DT3 3.0 0.0 1.0 C2' A:DT3 3.1 0.0 1.0 H5'' A:DC4 3.2 0.0 1.0 H3' A:DC4 3.4 0.0 1.0 H6 A:DC4 3.9 0.0 1.0 H2' A:DT3 3.9 0.0 1.0 C4' A:DC4 3.9 0.0 1.0 H1' A:DT3 3.9 0.0 1.0 C4' A:DT3 3.9 0.0 1.0 H4' A:DT3 4.0 0.0 1.0 C1' A:DT3 4.1 0.0 1.0 C3' A:DC4 4.1 0.0 1.0 H2' A:DC4 4.2 0.0 1.0 O4' A:DC4 4.6 0.0 1.0 O4' A:DT3 4.6 0.0 1.0 H4' A:DC4 4.7 0.0 1.0 C2' A:DC4 4.7 0.0 1.0 C6 A:DC4 4.9 0.0 1.0 O5' A:DT3 5.0 0.0 1.0

Phosphorus binding site 4 out of 22 in the uc(Nmr) Solution Structure of A Dna Dodecamer Duplex Containing A Cis- Diammineplatinum(II) D(Gpg) Intrastrand Cross-Link, the Major Adduct of the Anticancer Drug Cisplatin, 1 Structure


Mono view


Stereo pair view

A full contact list of Phosphorus with other atoms in the P binding site number 4 of uc(Nmr) Solution Structure of A Dna Dodecamer Duplex Containing A Cis- Diammineplatinum(II) D(Gpg) Intrastrand Cross-Link, the Major Adduct of the Anticancer Drug Cisplatin, 1 Structure within 5.0Å range: probe atom residue distance (Å) B Occ A:P5 b:0.0 occ:1.00 P A:DT5 0.0 0.0 1.0 OP1 A:DT5 1.5 0.0 1.0 OP2 A:DT5 1.5 0.0 1.0 O5' A:DT5 1.6 0.0 1.0 O3' A:DC4 1.6 0.0 1.0 C5' A:DT5 2.7 0.0 1.0 H5'' A:DT5 2.7 0.0 1.0 C3' A:DC4 2.7 0.0 1.0 H2'' A:DC4 2.8 0.0 1.0 H1' A:DC4 2.9 0.0 1.0 H4' A:DC4 3.1 0.0 1.0 C2' A:DC4 3.1 0.0 1.0 H5' A:DT5 3.2 0.0 1.0 C4' A:DC4 3.4 0.0 1.0 C1' A:DC4 3.4 0.0 1.0 H3' A:DC4 3.7 0.0 1.0 O4' A:DC4 3.7 0.0 1.0 H4' A:DT5 3.9 0.0 1.0 C4' A:DT5 3.9 0.0 1.0 H2' A:DC4 4.2 0.0 1.0 O4' A:DT5 4.7 0.0 1.0 N1 A:DC4 4.8 0.0 1.0 H3' A:DT5 4.8 0.0 1.0 C5' A:DC4 4.8 0.0 1.0 O2 A:DC4 4.9 0.0 1.0 H6 A:DT5 4.9 0.0 1.0

Phosphorus binding site 5 out of 22 in the uc(Nmr) Solution Structure of A Dna Dodecamer Duplex Containing A Cis- Diammineplatinum(II) D(Gpg) Intrastrand Cross-Link, the Major Adduct of the Anticancer Drug Cisplatin, 1 Structure


Mono view


Stereo pair view

A full contact list of Phosphorus with other atoms in the P binding site number 5 of uc(Nmr) Solution Structure of A Dna Dodecamer Duplex Containing A Cis- Diammineplatinum(II) D(Gpg) Intrastrand Cross-Link, the Major Adduct of the Anticancer Drug Cisplatin, 1 Structure within 5.0Å range: probe atom residue distance (Å) B Occ A:P6 b:0.0 occ:1.00 P A:DG6 0.0 0.0 1.0 OP1 A:DG6 1.5 0.0 1.0 OP2 A:DG6 1.5 0.0 1.0 O5' A:DG6 1.6 0.0 1.0 O3' A:DT5 1.6 0.0 1.0 H2'' A:DT5 2.6 0.0 1.0 C5' A:DG6 2.6 0.0 1.0 C3' A:DT5 2.7 0.0 1.0 H5' A:DG6 2.7 0.0 1.0 H3' A:DT5 2.9 0.0 1.0 H5'' A:DG6 3.1 0.0 1.0 C2' A:DT5 3.1 0.0 1.0 H2' A:DT5 3.8 0.0 1.0 C4' A:DG6 3.9 0.0 1.0 C4' A:DT5 3.9 0.0 1.0 H4' A:DG6 4.0 0.0 1.0 H4' A:DT5 4.0 0.0 1.0 C1' A:DT5 4.3 0.0 1.0 H1' A:DT5 4.4 0.0 1.0 O4' A:DG6 4.4 0.0 1.0 O4' A:DT5 4.6 0.0 1.0 OP2 A:DG7 5.0 0.0 1.0 H5' A:DT5 5.0 0.0 1.0

Phosphorus binding site 6 out of 22 in the uc(Nmr) Solution Structure of A Dna Dodecamer Duplex Containing A Cis- Diammineplatinum(II) D(Gpg) Intrastrand Cross-Link, the Major Adduct of the Anticancer Drug Cisplatin, 1 Structure


Mono view


Stereo pair view

A full contact list of Phosphorus with other atoms in the P binding site number 6 of uc(Nmr) Solution Structure of A Dna Dodecamer Duplex Containing A Cis- Diammineplatinum(II) D(Gpg) Intrastrand Cross-Link, the Major Adduct of the Anticancer Drug Cisplatin, 1 Structure within 5.0Å range: probe atom residue distance (Å) B Occ A:P7 b:0.0 occ:1.00 P A:DG7 0.0 0.0 1.0 OP1 A:DG7 1.5 0.0 1.0 OP2 A:DG7 1.5 0.0 1.0 O3' A:DG6 1.6 0.0 1.0 O5' A:DG7 1.6 0.0 1.0 C3' A:DG6 2.6 0.0 1.0 C5' A:DG7 2.6 0.0 1.0 H3' A:DG6 2.6 0.0 1.0 H4' A:DG7 2.7 0.0 1.0 H5' A:DG7 2.9 0.0 1.0 C4' A:DG7 3.1 0.0 1.0 H5' A:DG6 3.3 0.0 1.0 O4' A:DG7 3.5 0.0 1.0 C4' A:DG6 3.5 0.0 1.0 H5'' A:DG7 3.5 0.0 1.0 H4' A:DG6 3.6 0.0 1.0 C5' A:DG6 3.8 0.0 1.0 C2' A:DG6 3.9 0.0 1.0 H2'' A:DG6 4.1 0.0 1.0 H2' A:DG6 4.2 0.0 1.0 H5'' A:DG6 4.3 0.0 1.0 C3' A:DG7 4.5 0.0 1.0 O4' A:DG6 4.8 0.0 1.0 H8 A:DG6 4.8 0.0 1.0 H3' A:DG7 4.9 0.0 1.0 C1' A:DG7 4.9 0.0 1.0 C1' A:DG6 5.0 0.0 1.0 O3' A:DG7 5.0 0.0 1.0

Phosphorus binding site 7 out of 22 in the uc(Nmr) Solution Structure of A Dna Dodecamer Duplex Containing A Cis- Diammineplatinum(II) D(Gpg) Intrastrand Cross-Link, the Major Adduct of the Anticancer Drug Cisplatin, 1 Structure


Mono view


Stereo pair view

A full contact list of Phosphorus with other atoms in the P binding site number 7 of uc(Nmr) Solution Structure of A Dna Dodecamer Duplex Containing A Cis- Diammineplatinum(II) D(Gpg) Intrastrand Cross-Link, the Major Adduct of the Anticancer Drug Cisplatin, 1 Structure within 5.0Å range: probe atom residue distance (Å) B Occ A:P8 b:0.0 occ:1.00 P A:DT8 0.0 0.0 1.0 OP2 A:DT8 1.5 0.0 1.0 OP1 A:DT8 1.5 0.0 1.0 O3' A:DG7 1.6 0.0 1.0 O5' A:DT8 1.6 0.0 1.0 C5' A:DT8 2.6 0.0 1.0 C3' A:DG7 2.6 0.0 1.0 H3' A:DG7 2.7 0.0 1.0 H5' A:DT8 2.8 0.0 1.0 H5'' A:DT8 2.9 0.0 1.0 H2'' A:DG7 3.2 0.0 1.0 C2' A:DG7 3.5 0.0 1.0 H4' A:DG7 3.8 0.0 1.0 C4' A:DG7 3.8 0.0 1.0 C4' A:DT8 3.9 0.0 1.0 H4' A:DT8 4.1 0.0 1.0 H2' A:DG7 4.2 0.0 1.0 O4' A:DT8 4.3 0.0 1.0 C1' A:DG7 4.5 0.0 1.0 H1' A:DG7 4.5 0.0 1.0 H6 A:DT8 4.6 0.0 1.0 O4' A:DG7 4.7 0.0 1.0 H5' A:DG7 4.8 0.0 1.0 C5' A:DG7 4.9 0.0 1.0

Phosphorus binding site 8 out of 22 in the uc(Nmr) Solution Structure of A Dna Dodecamer Duplex Containing A Cis- Diammineplatinum(II) D(Gpg) Intrastrand Cross-Link, the Major Adduct of the Anticancer Drug Cisplatin, 1 Structure


Mono view


Stereo pair view

A full contact list of Phosphorus with other atoms in the P binding site number 8 of uc(Nmr) Solution Structure of A Dna Dodecamer Duplex Containing A Cis- Diammineplatinum(II) D(Gpg) Intrastrand Cross-Link, the Major Adduct of the Anticancer Drug Cisplatin, 1 Structure within 5.0Å range: probe atom residue distance (Å) B Occ A:P9 b:0.0 occ:1.00 P A:DC9 0.0 0.0 1.0 OP2 A:DC9 1.5 0.0 1.0 OP1 A:DC9 1.5 0.0 1.0 O5' A:DC9 1.6 0.0 1.0 O3' A:DT8 1.6 0.0 1.0 H2'' A:DT8 2.5 0.0 1.0 C5' A:DC9 2.6 0.0 1.0 C3' A:DT8 2.7 0.0 1.0 H5'' A:DC9 2.7 0.0 1.0 H3' A:DT8 3.0 0.0 1.0 C2' A:DT8 3.0 0.0 1.0 H5' A:DC9 3.0 0.0 1.0 H3' A:DC9 3.7 0.0 1.0 H6 A:DC9 3.8 0.0 1.0 H1' A:DT8 3.8 0.0 1.0 H2' A:DT8 3.9 0.0 1.0 C4' A:DC9 3.9 0.0 1.0 C1' A:DT8 3.9 0.0 1.0 C4' A:DT8 4.0 0.0 1.0 H4' A:DT8 4.0 0.0 1.0 C3' A:DC9 4.3 0.0 1.0 H2' A:DC9 4.3 0.0 1.0 O4' A:DT8 4.4 0.0 1.0 O4' A:DC9 4.5 0.0 1.0 C6 A:DC9 4.7 0.0 1.0 H4' A:DC9 4.7 0.0 1.0 C2' A:DC9 4.8 0.0 1.0

Phosphorus binding site 9 out of 22 in the uc(Nmr) Solution Structure of A Dna Dodecamer Duplex Containing A Cis- Diammineplatinum(II) D(Gpg) Intrastrand Cross-Link, the Major Adduct of the Anticancer Drug Cisplatin, 1 Structure


Mono view


Stereo pair view

A full contact list of Phosphorus with other atoms in the P binding site number 9 of uc(Nmr) Solution Structure of A Dna Dodecamer Duplex Containing A Cis- Diammineplatinum(II) D(Gpg) Intrastrand Cross-Link, the Major Adduct of the Anticancer Drug Cisplatin, 1 Structure within 5.0Å range: probe atom residue distance (Å) B Occ A:P10 b:0.0 occ:1.00 P A:DT10 0.0 0.0 1.0 OP1 A:DT10 1.5 0.0 1.0 OP2 A:DT10 1.5 0.0 1.0 O5' A:DT10 1.6 0.0 1.0 O3' A:DC9 1.6 0.0 1.0 C3' A:DC9 2.6 0.0 1.0 C5' A:DT10 2.6 0.0 1.0 H2'' A:DC9 2.7 0.0 1.0 H5'' A:DT10 2.8 0.0 1.0 H3' A:DC9 2.8 0.0 1.0 H5' A:DT10 2.9 0.0 1.0 C2' A:DC9 3.2 0.0 1.0 H2' A:DC9 3.9 0.0 1.0 H3' A:DT10 3.9 0.0 1.0 C4' A:DC9 3.9 0.0 1.0 C4' A:DT10 3.9 0.0 1.0 H4' A:DC9 4.0 0.0 1.0 H6 A:DT10 4.0 0.0 1.0 H2' A:DT10 4.2 0.0 1.0 H1' A:DC9 4.2 0.0 1.0 C1' A:DC9 4.3 0.0 1.0 C3' A:DT10 4.4 0.0 1.0 O4' A:DT10 4.4 0.0 1.0 O4' A:DC9 4.7 0.0 1.0 H4' A:DT10 4.8 0.0 1.0 C2' A:DT10 4.8 0.0 1.0 H5'' A:DC9 4.9 0.0 1.0 C6 A:DT10 4.9 0.0 1.0

Phosphorus binding site 10 out of 22 in the uc(Nmr) Solution Structure of A Dna Dodecamer Duplex Containing A Cis- Diammineplatinum(II) D(Gpg) Intrastrand Cross-Link, the Major Adduct of the Anticancer Drug Cisplatin, 1 Structure


Mono view


Stereo pair view

A full contact list of Phosphorus with other atoms in the P binding site number 10 of uc(Nmr) Solution Structure of A Dna Dodecamer Duplex Containing A Cis- Diammineplatinum(II) D(Gpg) Intrastrand Cross-Link, the Major Adduct of the Anticancer Drug Cisplatin, 1 Structure within 5.0Å range: probe atom residue distance (Å) B Occ A:P11 b:0.0 occ:1.00 P A:DC11 0.0 0.0 1.0 OP2 A:DC11 1.5 0.0 1.0 OP1 A:DC11 1.5 0.0 1.0 O5' A:DC11 1.6 0.0 1.0 O3' A:DT10 1.6 0.0 1.0 H2'' A:DT10 2.5 0.0 1.0 C5' A:DC11 2.6 0.0 1.0 H5' A:DC11 2.6 0.0 1.0 C3' A:DT10 2.6 0.0 1.0 H6 A:DC11 2.8 0.0 1.0 H3' A:DT10 3.0 0.0 1.0 C2' A:DT10 3.0 0.0 1.0 H5'' A:DC11 3.3 0.0 1.0 C6 A:DC11 3.6 0.0 1.0 H1' A:DT10 3.7 0.0 1.0 C4' A:DC11 3.8 0.0 1.0 O4' A:DC11 3.8 0.0 1.0 H2' A:DT10 3.8 0.0 1.0 C4' A:DT10 3.9 0.0 1.0 C1' A:DT10 4.0 0.0 1.0 H4' A:DT10 4.0 0.0 1.0 H5 A:DC11 4.1 0.0 1.0 C5 A:DC11 4.2 0.0 1.0 H2' A:DC11 4.3 0.0 1.0 N1 A:DC11 4.4 0.0 1.0 H3' A:DC11 4.4 0.0 1.0 C1' A:DC11 4.5 0.0 1.0 C3' A:DC11 4.5 0.0 1.0 O4' A:DT10 4.5 0.0 1.0 H4' A:DC11 4.6 0.0 1.0 C2' A:DC11 4.7 0.0 1.0

A.Gelasco, S.J.Lippard. uc(Nmr) Solution Structure of A Dna Dodecamer Duplex Containing A Cis-Diammineplatinum(II) D(Gpg) Intrastrand Cross-Link, the Major Adduct of the Anticancer Drug Cisplatin. Biochemistry V. 37 9230 1998.
ISSN: ISSN 0006-2960
PubMed: 9649303
DOI: 10.1021/BI973176V