Phosphorus in PDB 1a81: Crystal Structure of the Tandem SH2 Domain of the Syk Kinase Bound to A Dually Tyrosine-Phosphorylated Itam
Enzymatic activity of Crystal Structure of the Tandem SH2 Domain of the Syk Kinase Bound to A Dually Tyrosine-Phosphorylated Itam
All present enzymatic activity of Crystal Structure of the Tandem SH2 Domain of the Syk Kinase Bound to A Dually Tyrosine-Phosphorylated Itam:
2.7.1.112;
Protein crystallography data
The structure of Crystal Structure of the Tandem SH2 Domain of the Syk Kinase Bound to A Dually Tyrosine-Phosphorylated Itam, PDB code: 1a81
was solved by
K.Fuetterer,
G.Waksman,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Resolution Low / High (Å)
|
30.00 /
3.00
|
Space group
|
P 1 21 1
|
Cell size a, b, c (Å), α, β, γ (°)
|
85.500,
146.900,
91.500,
90.00,
97.60,
90.00
|
R / Rfree (%)
|
22.6 /
31.7
|
Phosphorus Binding Sites:
Pages:
>>> Page 1 <<<
Page 2, Binding sites: 11 -
12;
Binding sites:
The binding sites of Phosphorus atom in the Crystal Structure of the Tandem SH2 Domain of the Syk Kinase Bound to A Dually Tyrosine-Phosphorylated Itam
(pdb code 1a81). This binding sites where shown within
5.0 Angstroms radius around Phosphorus atom.
In total 12 binding sites of Phosphorus where determined in the
Crystal Structure of the Tandem SH2 Domain of the Syk Kinase Bound to A Dually Tyrosine-Phosphorylated Itam, PDB code: 1a81:
Jump to Phosphorus binding site number:
1;
2;
3;
4;
5;
6;
7;
8;
9;
10;
Phosphorus binding site 1 out
of 12 in 1a81
Go back to
Phosphorus Binding Sites List in 1a81
Phosphorus binding site 1 out
of 12 in the Crystal Structure of the Tandem SH2 Domain of the Syk Kinase Bound to A Dually Tyrosine-Phosphorylated Itam
 Mono view
 Stereo pair view
|
A full contact list of Phosphorus with other atoms in the P binding
site number 1 of Crystal Structure of the Tandem SH2 Domain of the Syk Kinase Bound to A Dually Tyrosine-Phosphorylated Itam within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
B:P170
b:36.7
occ:1.00
|
P
|
B:PTR170
|
0.0
|
36.7
|
1.0
|
O1P
|
B:PTR170
|
1.5
|
35.0
|
1.0
|
O3P
|
B:PTR170
|
1.5
|
28.0
|
1.0
|
O2P
|
B:PTR170
|
1.5
|
28.9
|
1.0
|
OH
|
B:PTR170
|
1.8
|
33.0
|
1.0
|
CZ
|
B:PTR170
|
2.8
|
33.2
|
1.0
|
NH1
|
A:ARG175
|
3.2
|
24.9
|
1.0
|
CE1
|
B:PTR170
|
3.4
|
32.2
|
1.0
|
NH1
|
A:ARG195
|
3.4
|
10.2
|
1.0
|
NH1
|
A:ARG197
|
3.6
|
59.2
|
1.0
|
CE2
|
B:PTR170
|
3.9
|
32.7
|
1.0
|
NH2
|
A:ARG195
|
3.9
|
7.0
|
1.0
|
CZ
|
A:ARG195
|
4.1
|
11.4
|
1.0
|
CD
|
A:ARG197
|
4.4
|
56.8
|
1.0
|
CB
|
A:ARG175
|
4.4
|
17.1
|
1.0
|
CG
|
A:ARG175
|
4.4
|
19.1
|
1.0
|
CD
|
B:PRO168
|
4.4
|
71.7
|
1.0
|
CZ
|
A:ARG175
|
4.4
|
27.3
|
1.0
|
CG
|
A:ARG197
|
4.6
|
56.2
|
1.0
|
CZ
|
A:ARG197
|
4.7
|
59.4
|
1.0
|
CD1
|
B:PTR170
|
4.7
|
34.8
|
1.0
|
NE
|
A:ARG197
|
5.0
|
58.1
|
1.0
|
|
Phosphorus binding site 2 out
of 12 in 1a81
Go back to
Phosphorus Binding Sites List in 1a81
Phosphorus binding site 2 out
of 12 in the Crystal Structure of the Tandem SH2 Domain of the Syk Kinase Bound to A Dually Tyrosine-Phosphorylated Itam
 Mono view
 Stereo pair view
|
A full contact list of Phosphorus with other atoms in the P binding
site number 2 of Crystal Structure of the Tandem SH2 Domain of the Syk Kinase Bound to A Dually Tyrosine-Phosphorylated Itam within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
B:P181
b:24.7
occ:1.00
|
P
|
B:PTR181
|
0.0
|
24.7
|
1.0
|
O1P
|
B:PTR181
|
1.5
|
22.1
|
1.0
|
O3P
|
B:PTR181
|
1.5
|
22.8
|
1.0
|
OH
|
B:PTR181
|
1.5
|
25.1
|
1.0
|
O2P
|
B:PTR181
|
1.5
|
18.9
|
1.0
|
CZ
|
B:PTR181
|
2.6
|
27.5
|
1.0
|
NH1
|
A:ARG22
|
2.9
|
15.6
|
1.0
|
CE1
|
B:PTR181
|
3.2
|
29.6
|
1.0
|
CE2
|
B:PTR181
|
3.7
|
23.9
|
1.0
|
NH1
|
A:ARG42
|
3.7
|
10.9
|
1.0
|
NZ
|
A:LYS232
|
4.0
|
44.0
|
1.0
|
CB
|
A:ARG22
|
4.2
|
12.2
|
1.0
|
CZ
|
A:ARG22
|
4.3
|
26.4
|
1.0
|
NH2
|
A:ARG42
|
4.3
|
13.1
|
1.0
|
OD1
|
A:ASN46
|
4.4
|
19.7
|
1.0
|
CZ
|
A:ARG42
|
4.5
|
8.5
|
1.0
|
CD1
|
B:PTR181
|
4.5
|
29.8
|
1.0
|
CD2
|
B:PTR181
|
4.9
|
29.3
|
1.0
|
|
Phosphorus binding site 3 out
of 12 in 1a81
Go back to
Phosphorus Binding Sites List in 1a81
Phosphorus binding site 3 out
of 12 in the Crystal Structure of the Tandem SH2 Domain of the Syk Kinase Bound to A Dually Tyrosine-Phosphorylated Itam
 Mono view
 Stereo pair view
|
A full contact list of Phosphorus with other atoms in the P binding
site number 3 of Crystal Structure of the Tandem SH2 Domain of the Syk Kinase Bound to A Dually Tyrosine-Phosphorylated Itam within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
D:P170
b:61.1
occ:1.00
|
P
|
D:PTR170
|
0.0
|
61.1
|
1.0
|
O2P
|
D:PTR170
|
1.5
|
60.6
|
1.0
|
O1P
|
D:PTR170
|
1.5
|
57.5
|
1.0
|
O3P
|
D:PTR170
|
1.5
|
58.1
|
1.0
|
OH
|
D:PTR170
|
1.6
|
58.1
|
1.0
|
CZ
|
D:PTR170
|
2.7
|
52.2
|
1.0
|
NH1
|
C:ARG197
|
3.0
|
46.8
|
1.0
|
CE2
|
D:PTR170
|
3.4
|
46.3
|
1.0
|
NH1
|
C:ARG195
|
3.5
|
20.5
|
1.0
|
CE1
|
D:PTR170
|
3.7
|
46.4
|
1.0
|
NH1
|
C:ARG175
|
3.9
|
73.4
|
1.0
|
CZ
|
C:ARG197
|
3.9
|
47.4
|
1.0
|
NH2
|
C:ARG197
|
4.0
|
41.0
|
1.0
|
CB
|
C:ARG175
|
4.0
|
55.2
|
1.0
|
CD
|
C:ARG175
|
4.1
|
64.6
|
1.0
|
NH2
|
C:ARG195
|
4.4
|
25.8
|
1.0
|
CZ
|
C:ARG195
|
4.4
|
22.9
|
1.0
|
CD
|
D:PRO168
|
4.6
|
67.1
|
1.0
|
CD2
|
D:PTR170
|
4.6
|
42.8
|
1.0
|
N
|
D:PRO168
|
4.7
|
67.5
|
1.0
|
CG
|
C:ARG175
|
4.7
|
59.7
|
1.0
|
CZ
|
C:ARG175
|
4.9
|
70.9
|
1.0
|
CD1
|
D:PTR170
|
4.9
|
42.3
|
1.0
|
NE
|
C:ARG175
|
5.0
|
70.2
|
1.0
|
NE
|
C:ARG197
|
5.0
|
49.2
|
1.0
|
|
Phosphorus binding site 4 out
of 12 in 1a81
Go back to
Phosphorus Binding Sites List in 1a81
Phosphorus binding site 4 out
of 12 in the Crystal Structure of the Tandem SH2 Domain of the Syk Kinase Bound to A Dually Tyrosine-Phosphorylated Itam
 Mono view
 Stereo pair view
|
A full contact list of Phosphorus with other atoms in the P binding
site number 4 of Crystal Structure of the Tandem SH2 Domain of the Syk Kinase Bound to A Dually Tyrosine-Phosphorylated Itam within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
D:P181
b:17.7
occ:1.00
|
P
|
D:PTR181
|
0.0
|
17.7
|
1.0
|
O1P
|
D:PTR181
|
1.5
|
23.3
|
1.0
|
O3P
|
D:PTR181
|
1.5
|
6.9
|
1.0
|
O2P
|
D:PTR181
|
1.6
|
5.4
|
1.0
|
OH
|
D:PTR181
|
1.6
|
4.7
|
1.0
|
CZ
|
D:PTR181
|
2.6
|
9.7
|
1.0
|
CE2
|
D:PTR181
|
3.0
|
10.9
|
1.0
|
NH1
|
C:ARG42
|
3.3
|
4.7
|
1.0
|
NH1
|
C:ARG22
|
3.5
|
23.7
|
1.0
|
NZ
|
C:LYS232
|
3.6
|
29.0
|
1.0
|
NH2
|
C:ARG42
|
3.8
|
4.7
|
1.0
|
CE1
|
D:PTR181
|
3.8
|
10.7
|
1.0
|
CZ
|
C:ARG42
|
4.0
|
4.7
|
1.0
|
CD2
|
D:PTR181
|
4.4
|
9.8
|
1.0
|
CB
|
C:ARG22
|
4.5
|
4.7
|
1.0
|
CZ
|
C:ARG22
|
4.8
|
20.5
|
1.0
|
CD
|
C:ARG22
|
4.9
|
17.1
|
1.0
|
CD1
|
D:PTR181
|
5.0
|
12.8
|
1.0
|
CA
|
C:ARG22
|
5.0
|
8.8
|
1.0
|
|
Phosphorus binding site 5 out
of 12 in 1a81
Go back to
Phosphorus Binding Sites List in 1a81
Phosphorus binding site 5 out
of 12 in the Crystal Structure of the Tandem SH2 Domain of the Syk Kinase Bound to A Dually Tyrosine-Phosphorylated Itam
 Mono view
 Stereo pair view
|
A full contact list of Phosphorus with other atoms in the P binding
site number 5 of Crystal Structure of the Tandem SH2 Domain of the Syk Kinase Bound to A Dually Tyrosine-Phosphorylated Itam within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
F:P170
b:100.0
occ:1.00
|
P
|
F:PTR170
|
0.0
|
100.0
|
1.0
|
O3P
|
F:PTR170
|
1.5
|
100.0
|
1.0
|
O2P
|
F:PTR170
|
1.5
|
100.0
|
1.0
|
O1P
|
F:PTR170
|
1.5
|
100.0
|
1.0
|
OH
|
F:PTR170
|
1.7
|
100.0
|
1.0
|
CZ
|
F:PTR170
|
2.8
|
100.0
|
1.0
|
CE1
|
F:PTR170
|
3.5
|
100.0
|
1.0
|
CZ
|
E:ARG197
|
3.5
|
87.8
|
1.0
|
NH1
|
E:ARG197
|
3.6
|
86.2
|
1.0
|
NH1
|
E:ARG195
|
3.6
|
53.3
|
1.0
|
CE2
|
F:PTR170
|
3.7
|
100.0
|
1.0
|
NE
|
E:ARG197
|
3.7
|
89.1
|
1.0
|
NH2
|
E:ARG195
|
3.9
|
53.7
|
1.0
|
NH2
|
E:ARG197
|
4.0
|
85.9
|
1.0
|
CD
|
E:ARG197
|
4.1
|
87.1
|
1.0
|
CZ
|
E:ARG195
|
4.2
|
53.6
|
1.0
|
NH1
|
E:ARG175
|
4.2
|
94.9
|
1.0
|
CB
|
E:ARG175
|
4.7
|
69.6
|
1.0
|
CD
|
F:PRO168
|
4.7
|
91.9
|
1.0
|
CD1
|
F:PTR170
|
4.7
|
97.5
|
1.0
|
CD
|
E:ARG175
|
4.8
|
84.4
|
1.0
|
CD2
|
F:PTR170
|
4.9
|
98.8
|
1.0
|
N
|
F:PRO168
|
5.0
|
94.1
|
1.0
|
|
Phosphorus binding site 6 out
of 12 in 1a81
Go back to
Phosphorus Binding Sites List in 1a81
Phosphorus binding site 6 out
of 12 in the Crystal Structure of the Tandem SH2 Domain of the Syk Kinase Bound to A Dually Tyrosine-Phosphorylated Itam
 Mono view
 Stereo pair view
|
A full contact list of Phosphorus with other atoms in the P binding
site number 6 of Crystal Structure of the Tandem SH2 Domain of the Syk Kinase Bound to A Dually Tyrosine-Phosphorylated Itam within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
F:P181
b:63.2
occ:1.00
|
P
|
F:PTR181
|
0.0
|
63.2
|
1.0
|
O2P
|
F:PTR181
|
1.5
|
59.8
|
1.0
|
O1P
|
F:PTR181
|
1.5
|
65.3
|
1.0
|
O3P
|
F:PTR181
|
1.5
|
59.1
|
1.0
|
OH
|
F:PTR181
|
1.6
|
61.7
|
1.0
|
CZ
|
F:PTR181
|
2.6
|
65.4
|
1.0
|
CE2
|
F:PTR181
|
3.0
|
64.2
|
1.0
|
NH1
|
E:ARG22
|
3.3
|
31.6
|
1.0
|
NH1
|
E:ARG42
|
3.4
|
41.0
|
1.0
|
CE1
|
F:PTR181
|
3.7
|
66.8
|
1.0
|
CB
|
E:ARG22
|
4.2
|
9.7
|
1.0
|
NH2
|
E:ARG42
|
4.3
|
32.6
|
1.0
|
CZ
|
E:ARG42
|
4.3
|
38.9
|
1.0
|
CD2
|
F:PTR181
|
4.3
|
66.3
|
1.0
|
OD1
|
E:ASN46
|
4.5
|
56.4
|
1.0
|
CZ
|
E:ARG22
|
4.5
|
27.5
|
1.0
|
CE
|
E:LYS232
|
4.8
|
34.5
|
1.0
|
CA
|
E:ARG22
|
4.8
|
18.1
|
1.0
|
CD1
|
F:PTR181
|
4.9
|
68.8
|
1.0
|
N
|
E:ARG22
|
4.9
|
17.1
|
1.0
|
|
Phosphorus binding site 7 out
of 12 in 1a81
Go back to
Phosphorus Binding Sites List in 1a81
Phosphorus binding site 7 out
of 12 in the Crystal Structure of the Tandem SH2 Domain of the Syk Kinase Bound to A Dually Tyrosine-Phosphorylated Itam
 Mono view
 Stereo pair view
|
A full contact list of Phosphorus with other atoms in the P binding
site number 7 of Crystal Structure of the Tandem SH2 Domain of the Syk Kinase Bound to A Dually Tyrosine-Phosphorylated Itam within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
H:P170
b:34.6
occ:1.00
|
P
|
H:PTR170
|
0.0
|
34.6
|
1.0
|
O1P
|
H:PTR170
|
1.5
|
32.2
|
1.0
|
O2P
|
H:PTR170
|
1.5
|
27.4
|
1.0
|
O3P
|
H:PTR170
|
1.6
|
25.2
|
1.0
|
OH
|
H:PTR170
|
1.6
|
34.6
|
1.0
|
CZ
|
H:PTR170
|
2.6
|
33.8
|
1.0
|
NH1
|
G:ARG197
|
3.1
|
32.6
|
1.0
|
NH1
|
G:ARG175
|
3.2
|
30.4
|
1.0
|
CE2
|
H:PTR170
|
3.4
|
32.3
|
1.0
|
CE1
|
H:PTR170
|
3.4
|
30.2
|
1.0
|
NH2
|
A:ARG129
|
3.6
|
74.5
|
1.0
|
NH1
|
G:ARG195
|
3.7
|
22.5
|
1.0
|
CG
|
G:ARG175
|
3.8
|
14.8
|
1.0
|
NH2
|
G:ARG195
|
3.9
|
24.0
|
1.0
|
CZ
|
G:ARG197
|
4.0
|
37.9
|
1.0
|
NH2
|
G:ARG197
|
4.1
|
37.3
|
1.0
|
CB
|
G:ARG175
|
4.2
|
18.8
|
1.0
|
CZ
|
G:ARG195
|
4.3
|
24.4
|
1.0
|
CD
|
G:ARG175
|
4.3
|
20.1
|
1.0
|
CZ
|
G:ARG175
|
4.4
|
30.6
|
1.0
|
CD2
|
H:PTR170
|
4.6
|
30.5
|
1.0
|
CD1
|
H:PTR170
|
4.6
|
29.2
|
1.0
|
NE
|
G:ARG175
|
4.8
|
29.6
|
1.0
|
CD
|
H:PRO168
|
4.8
|
81.7
|
1.0
|
CZ
|
A:ARG129
|
4.8
|
74.5
|
1.0
|
N
|
H:PRO168
|
4.9
|
80.5
|
1.0
|
|
Phosphorus binding site 8 out
of 12 in 1a81
Go back to
Phosphorus Binding Sites List in 1a81
Phosphorus binding site 8 out
of 12 in the Crystal Structure of the Tandem SH2 Domain of the Syk Kinase Bound to A Dually Tyrosine-Phosphorylated Itam
 Mono view
 Stereo pair view
|
A full contact list of Phosphorus with other atoms in the P binding
site number 8 of Crystal Structure of the Tandem SH2 Domain of the Syk Kinase Bound to A Dually Tyrosine-Phosphorylated Itam within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
H:P181
b:18.0
occ:1.00
|
P
|
H:PTR181
|
0.0
|
18.0
|
1.0
|
O1P
|
H:PTR181
|
1.5
|
13.4
|
1.0
|
O3P
|
H:PTR181
|
1.5
|
14.3
|
1.0
|
O2P
|
H:PTR181
|
1.5
|
11.9
|
1.0
|
OH
|
H:PTR181
|
1.5
|
15.5
|
1.0
|
CZ
|
H:PTR181
|
2.6
|
17.8
|
1.0
|
CE1
|
H:PTR181
|
3.3
|
19.1
|
1.0
|
NH1
|
G:ARG42
|
3.3
|
8.9
|
1.0
|
NH1
|
G:ARG22
|
3.4
|
4.7
|
1.0
|
CE2
|
H:PTR181
|
3.5
|
15.8
|
1.0
|
CB
|
G:ARG22
|
3.9
|
6.2
|
1.0
|
CZ
|
G:ARG42
|
4.3
|
6.5
|
1.0
|
NH2
|
G:ARG42
|
4.4
|
4.7
|
1.0
|
CD1
|
H:PTR181
|
4.6
|
18.9
|
1.0
|
CZ
|
G:ARG22
|
4.6
|
13.3
|
1.0
|
CD2
|
H:PTR181
|
4.7
|
18.8
|
1.0
|
OD1
|
G:ASN46
|
4.8
|
21.6
|
1.0
|
CA
|
G:ARG22
|
4.8
|
8.1
|
1.0
|
CG
|
G:ARG22
|
4.8
|
4.7
|
1.0
|
N
|
G:ARG22
|
5.0
|
4.8
|
1.0
|
|
Phosphorus binding site 9 out
of 12 in 1a81
Go back to
Phosphorus Binding Sites List in 1a81
Phosphorus binding site 9 out
of 12 in the Crystal Structure of the Tandem SH2 Domain of the Syk Kinase Bound to A Dually Tyrosine-Phosphorylated Itam
 Mono view
 Stereo pair view
|
A full contact list of Phosphorus with other atoms in the P binding
site number 9 of Crystal Structure of the Tandem SH2 Domain of the Syk Kinase Bound to A Dually Tyrosine-Phosphorylated Itam within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
J:P170
b:100.0
occ:1.00
|
P
|
J:PTR170
|
0.0
|
100.0
|
1.0
|
O2P
|
J:PTR170
|
1.5
|
100.0
|
1.0
|
O3P
|
J:PTR170
|
1.5
|
100.0
|
1.0
|
O1P
|
J:PTR170
|
1.5
|
100.0
|
1.0
|
OH
|
J:PTR170
|
1.6
|
100.0
|
1.0
|
CZ
|
J:PTR170
|
2.6
|
100.0
|
1.0
|
CE1
|
J:PTR170
|
3.1
|
100.0
|
1.0
|
NH1
|
I:ARG175
|
3.4
|
89.7
|
1.0
|
NH1
|
I:ARG197
|
3.6
|
100.0
|
1.0
|
CE2
|
J:PTR170
|
3.6
|
100.0
|
1.0
|
NH1
|
I:ARG195
|
3.6
|
59.0
|
1.0
|
CD
|
I:ARG175
|
4.1
|
83.8
|
1.0
|
NH2
|
I:ARG195
|
4.2
|
55.9
|
1.0
|
CZ
|
I:ARG175
|
4.2
|
90.4
|
1.0
|
CZ
|
I:ARG195
|
4.4
|
60.0
|
1.0
|
CD1
|
J:PTR170
|
4.4
|
100.0
|
1.0
|
CB
|
I:ARG175
|
4.4
|
75.2
|
1.0
|
CZ
|
I:ARG197
|
4.5
|
100.0
|
1.0
|
NE
|
I:ARG175
|
4.5
|
88.8
|
1.0
|
NH2
|
I:ARG197
|
4.6
|
100.0
|
1.0
|
CD
|
J:PRO168
|
4.6
|
100.0
|
1.0
|
N
|
J:PRO168
|
4.7
|
100.0
|
1.0
|
CG
|
I:ARG175
|
4.7
|
79.1
|
1.0
|
CD2
|
J:PTR170
|
4.8
|
100.0
|
1.0
|
|
Phosphorus binding site 10 out
of 12 in 1a81
Go back to
Phosphorus Binding Sites List in 1a81
Phosphorus binding site 10 out
of 12 in the Crystal Structure of the Tandem SH2 Domain of the Syk Kinase Bound to A Dually Tyrosine-Phosphorylated Itam
 Mono view
 Stereo pair view
|
A full contact list of Phosphorus with other atoms in the P binding
site number 10 of Crystal Structure of the Tandem SH2 Domain of the Syk Kinase Bound to A Dually Tyrosine-Phosphorylated Itam within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
J:P181
b:36.1
occ:1.00
|
P
|
J:PTR181
|
0.0
|
36.1
|
1.0
|
O1P
|
J:PTR181
|
1.5
|
36.2
|
1.0
|
OH
|
J:PTR181
|
1.5
|
34.5
|
1.0
|
O3P
|
J:PTR181
|
1.5
|
28.8
|
1.0
|
O2P
|
J:PTR181
|
1.5
|
30.8
|
1.0
|
CZ
|
J:PTR181
|
2.5
|
37.5
|
1.0
|
NH1
|
I:ARG22
|
2.7
|
16.5
|
1.0
|
NH1
|
I:ARG42
|
3.1
|
4.7
|
1.0
|
CE2
|
J:PTR181
|
3.2
|
37.2
|
1.0
|
CE1
|
J:PTR181
|
3.6
|
41.3
|
1.0
|
CB
|
I:ARG22
|
3.8
|
6.9
|
1.0
|
NH2
|
I:ARG42
|
3.8
|
8.5
|
1.0
|
CZ
|
I:ARG42
|
3.9
|
7.2
|
1.0
|
CZ
|
I:ARG22
|
3.9
|
23.1
|
1.0
|
CD2
|
J:PTR181
|
4.6
|
40.9
|
1.0
|
CA
|
I:ARG22
|
4.6
|
7.1
|
1.0
|
CD
|
I:ARG22
|
4.6
|
16.0
|
1.0
|
NE
|
I:ARG22
|
4.7
|
22.4
|
1.0
|
CG
|
I:ARG22
|
4.7
|
4.7
|
1.0
|
CD1
|
J:PTR181
|
4.8
|
42.6
|
1.0
|
NH2
|
I:ARG22
|
4.8
|
25.8
|
1.0
|
N
|
I:ARG22
|
4.8
|
4.7
|
1.0
|
|
Reference:
K.Futterer,
J.Wong,
R.A.Grucza,
A.C.Chan,
G.Waksman.
Structural Basis For Syk Tyrosine Kinase Ubiquity in Signal Transduction Pathways Revealed By the Crystal Structure of Its Regulatory SH2 Domains Bound to A Dually Phosphorylated Itam Peptide. J.Mol.Biol. V. 281 523 1998.
ISSN: ISSN 0022-2836
PubMed: 9698567
DOI: 10.1006/JMBI.1998.1964
Page generated: Fri Sep 25 12:25:47 2020
|