Phosphorus in PDB 1a27: Human 17-Beta-Hydroxysteroid-Dehydrogenase Type 1 C-Terminal Deletion Mutant Complexed with Estradiol and Nadp+

Enzymatic activity of Human 17-Beta-Hydroxysteroid-Dehydrogenase Type 1 C-Terminal Deletion Mutant Complexed with Estradiol and Nadp+

All present enzymatic activity of Human 17-Beta-Hydroxysteroid-Dehydrogenase Type 1 C-Terminal Deletion Mutant Complexed with Estradiol and Nadp+:
1.1.1.62;

Protein crystallography data

The structure of Human 17-Beta-Hydroxysteroid-Dehydrogenase Type 1 C-Terminal Deletion Mutant Complexed with Estradiol and Nadp+, PDB code: 1a27 was solved by C.Mazza, R.Breton, D.Housset, J.-C.Fontecilla-Camps, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 10.00 / 1.90
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 111.380, 48.540, 60.770, 90.00, 115.13, 90.00
R / Rfree (%) 21 / 26.1

Phosphorus Binding Sites:

The binding sites of Phosphorus atom in the Human 17-Beta-Hydroxysteroid-Dehydrogenase Type 1 C-Terminal Deletion Mutant Complexed with Estradiol and Nadp+ (pdb code 1a27). This binding sites where shown within 5.0 Angstroms radius around Phosphorus atom.
In total 3 binding sites of Phosphorus where determined in the Human 17-Beta-Hydroxysteroid-Dehydrogenase Type 1 C-Terminal Deletion Mutant Complexed with Estradiol and Nadp+, PDB code: 1a27:
Jump to Phosphorus binding site number: 1; 2; 3;

Phosphorus binding site 1 out of 3 in 1a27

Go back to Phosphorus Binding Sites List in 1a27
Phosphorus binding site 1 out of 3 in the Human 17-Beta-Hydroxysteroid-Dehydrogenase Type 1 C-Terminal Deletion Mutant Complexed with Estradiol and Nadp+


Mono view


Stereo pair view

A full contact list of Phosphorus with other atoms in the P binding site number 1 of Human 17-Beta-Hydroxysteroid-Dehydrogenase Type 1 C-Terminal Deletion Mutant Complexed with Estradiol and Nadp+ within 5.0Å range:
probe atom residue distance (Å) B Occ
A:P360

b:39.8
occ:1.00
 PA A:NAP360 0.0 39.8 1.0
O1A A:NAP360 1.5 38.3 1.0
O2A A:NAP360 1.5 38.5 1.0
O3 A:NAP360 1.6 37.4 1.0
O5B A:NAP360 1.6 39.7 1.0
C5B A:NAP360 2.7 38.6 1.0
PN A:NAP360 2.9 38.8 1.0
O2N A:NAP360 3.2 37.1 1.0
OG A:SER12 3.5 27.4 1.0
O A:HOH603 3.6 50.4 1.0
O5D A:NAP360 3.6 37.5 1.0
O A:THR190 3.8 53.4 1.0
C4B A:NAP360 3.9 37.1 1.0
O A:HOH573 3.9 49.7 1.0
O1N A:NAP360 4.1 39.4 1.0
C3B A:NAP360 4.1 37.3 1.0
CA A:PHE192 4.2 71.5 0.5
CB A:PHE192 4.2 72.2 0.5
OG1 A:THR190 4.3 46.0 1.0
CB A:THR190 4.3 47.7 1.0
N A:PHE192 4.3 68.3 0.5
O A:HOH525 4.4 28.7 1.0
CD1 A:PHE192 4.5 73.0 0.5
C A:THR190 4.7 52.0 1.0
O A:HOH605 4.7 46.0 1.0
O A:HOH618 4.7 77.8 1.0
CB A:SER12 4.8 26.4 1.0
C A:ALA191 4.8 73.0 0.5
C5D A:NAP360 4.8 37.6 1.0
C A:SER12 4.8 25.0 1.0
O A:SER12 4.8 23.7 1.0
CG A:PHE192 4.8 72.8 0.5
N A:GLY13 4.8 25.6 1.0
CA A:GLY13 4.9 23.7 1.0
O4B A:NAP360 5.0 37.5 1.0

Phosphorus binding site 2 out of 3 in 1a27

Go back to Phosphorus Binding Sites List in 1a27
Phosphorus binding site 2 out of 3 in the Human 17-Beta-Hydroxysteroid-Dehydrogenase Type 1 C-Terminal Deletion Mutant Complexed with Estradiol and Nadp+


Mono view


Stereo pair view

A full contact list of Phosphorus with other atoms in the P binding site number 2 of Human 17-Beta-Hydroxysteroid-Dehydrogenase Type 1 C-Terminal Deletion Mutant Complexed with Estradiol and Nadp+ within 5.0Å range:
probe atom residue distance (Å) B Occ
A:P360

b:38.8
occ:1.00
 PN A:NAP360 0.0 38.8 1.0
O2N A:NAP360 1.5 37.1 1.0
O1N A:NAP360 1.5 39.4 1.0
O5D A:NAP360 1.6 37.5 1.0
O3 A:NAP360 1.6 37.4 1.0
C5D A:NAP360 2.7 37.6 1.0
O A:HOH618 2.9 77.8 1.0
PA A:NAP360 2.9 39.8 1.0
O5B A:NAP360 3.2 39.7 1.0
O2A A:NAP360 3.4 38.5 1.0
OG1 A:THR190 3.4 46.0 1.0
C5B A:NAP360 3.8 38.6 1.0
C4D A:NAP360 3.8 39.1 1.0
O4D A:NAP360 3.8 38.3 1.0
CB A:THR190 3.8 47.7 1.0
O A:HOH525 3.8 28.7 1.0
CG2 A:THR190 3.9 46.8 1.0
CB A:PHE192 4.0 72.2 0.5
N7N A:NAP360 4.1 42.2 1.0
O1A A:NAP360 4.1 38.3 1.0
CG A:PHE192 4.3 72.8 0.5
C2N A:NAP360 4.3 39.5 1.0
CD1 A:PHE192 4.4 73.0 0.5
C3D A:NAP360 4.5 38.3 1.0
N A:ILE14 4.5 22.8 1.0
CG1 A:ILE14 4.5 27.9 1.0
CA A:GLY13 4.7 23.7 1.0
C1D A:NAP360 4.7 38.8 1.0
C2D A:NAP360 4.8 39.2 1.0
CD1 A:ILE14 4.8 29.8 1.0
CA A:PHE192 4.9 71.5 0.5

Phosphorus binding site 3 out of 3 in 1a27

Go back to Phosphorus Binding Sites List in 1a27
Phosphorus binding site 3 out of 3 in the Human 17-Beta-Hydroxysteroid-Dehydrogenase Type 1 C-Terminal Deletion Mutant Complexed with Estradiol and Nadp+


Mono view


Stereo pair view

A full contact list of Phosphorus with other atoms in the P binding site number 3 of Human 17-Beta-Hydroxysteroid-Dehydrogenase Type 1 C-Terminal Deletion Mutant Complexed with Estradiol and Nadp+ within 5.0Å range:
probe atom residue distance (Å) B Occ
A:P360

b:46.9
occ:1.00
 P2B A:NAP360 0.0 46.9 1.0
O1X A:NAP360 1.4 47.6 1.0
O2B A:NAP360 1.4 42.5 1.0
O2X A:NAP360 1.4 45.8 1.0
O3X A:NAP360 1.4 47.2 1.0
C2B A:NAP360 2.5 38.6 1.0
C3B A:NAP360 3.5 37.3 1.0
O A:HOH550 3.6 21.9 1.0
C1B A:NAP360 3.7 37.2 1.0
OG A:SER11 3.7 28.0 1.0
O3B A:NAP360 3.8 34.2 1.0
CZ A:ARG37 3.8 52.0 1.0
O A:HOH605 3.8 46.0 1.0
O A:HOH524 3.8 18.8 1.0
NH1 A:ARG37 3.9 54.0 1.0
NH2 A:ARG37 3.9 50.5 1.0
N9A A:NAP360 4.0 36.3 1.0
C8A A:NAP360 4.2 34.6 1.0
NE A:ARG37 4.2 48.6 1.0
O A:HOH603 4.3 50.4 1.0
NZ A:LYS195 4.5 87.3 0.5
CB A:ARG37 4.7 30.5 1.0
CB A:SER11 4.7 22.8 1.0
C4A A:NAP360 4.7 35.6 1.0
C4B A:NAP360 4.8 37.1 1.0
O4B A:NAP360 4.8 37.5 1.0
CD A:ARG37 4.8 41.6 1.0
N7A A:NAP360 4.9 34.2 1.0

Reference:

C.Mazza, C.Mazza, R.Breton, D.Housset, J.-C.Fontecilla-Camps. N/A N/A.
Page generated: Fri Sep 25 12:02:54 2020

Last articles

Na in 5T9C
Na in 5T9B
Na in 5T26
Na in 5T91
Na in 5T7U
Na in 5T7M
Na in 5T77
Na in 5T6S
Na in 5T1Q
Na in 5T05
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy