Phosphorus in PDB 1a27: Human 17-Beta-Hydroxysteroid-Dehydrogenase Type 1 C-Terminal Deletion Mutant Complexed with Estradiol and Nadp+

Enzymatic activity of Human 17-Beta-Hydroxysteroid-Dehydrogenase Type 1 C-Terminal Deletion Mutant Complexed with Estradiol and Nadp+

All present enzymatic activity of Human 17-Beta-Hydroxysteroid-Dehydrogenase Type 1 C-Terminal Deletion Mutant Complexed with Estradiol and Nadp+:
1.1.1.62;

Protein crystallography data

The structure of Human 17-Beta-Hydroxysteroid-Dehydrogenase Type 1 C-Terminal Deletion Mutant Complexed with Estradiol and Nadp+, PDB code: 1a27 was solved by C.Mazza, R.Breton, D.Housset, J.-C.Fontecilla-Camps, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 10.00 / 1.90
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 111.380, 48.540, 60.770, 90.00, 115.13, 90.00
R / Rfree (%) 21 / 26.1

Phosphorus Binding Sites:

The binding sites of Phosphorus atom in the Human 17-Beta-Hydroxysteroid-Dehydrogenase Type 1 C-Terminal Deletion Mutant Complexed with Estradiol and Nadp+ (pdb code 1a27). This binding sites where shown within 5.0 Angstroms radius around Phosphorus atom.
In total 3 binding sites of Phosphorus where determined in the Human 17-Beta-Hydroxysteroid-Dehydrogenase Type 1 C-Terminal Deletion Mutant Complexed with Estradiol and Nadp+, PDB code: 1a27:
Jump to Phosphorus binding site number: 1; 2; 3;

Phosphorus binding site 1 out of 3 in 1a27

Go back to Phosphorus Binding Sites List in 1a27
Phosphorus binding site 1 out of 3 in the Human 17-Beta-Hydroxysteroid-Dehydrogenase Type 1 C-Terminal Deletion Mutant Complexed with Estradiol and Nadp+


Mono view


Stereo pair view

A full contact list of Phosphorus with other atoms in the P binding site number 1 of Human 17-Beta-Hydroxysteroid-Dehydrogenase Type 1 C-Terminal Deletion Mutant Complexed with Estradiol and Nadp+ within 5.0Å range:
probe atom residue distance (Å) B Occ
A:P360

b:39.8
occ:1.00
PA A:NAP360 0.0 39.8 1.0
O1A A:NAP360 1.5 38.3 1.0
O2A A:NAP360 1.5 38.5 1.0
O3 A:NAP360 1.6 37.4 1.0
O5B A:NAP360 1.6 39.7 1.0
C5B A:NAP360 2.7 38.6 1.0
PN A:NAP360 2.9 38.8 1.0
O2N A:NAP360 3.2 37.1 1.0
OG A:SER12 3.5 27.4 1.0
O A:HOH603 3.6 50.4 1.0
O5D A:NAP360 3.6 37.5 1.0
O A:THR190 3.8 53.4 1.0
C4B A:NAP360 3.9 37.1 1.0
O A:HOH573 3.9 49.7 1.0
O1N A:NAP360 4.1 39.4 1.0
C3B A:NAP360 4.1 37.3 1.0
CA A:PHE192 4.2 71.5 0.5
CB A:PHE192 4.2 72.2 0.5
OG1 A:THR190 4.3 46.0 1.0
CB A:THR190 4.3 47.7 1.0
N A:PHE192 4.3 68.3 0.5
O A:HOH525 4.4 28.7 1.0
CD1 A:PHE192 4.5 73.0 0.5
C A:THR190 4.7 52.0 1.0
O A:HOH605 4.7 46.0 1.0
O A:HOH618 4.7 77.8 1.0
CB A:SER12 4.8 26.4 1.0
C A:ALA191 4.8 73.0 0.5
C5D A:NAP360 4.8 37.6 1.0
C A:SER12 4.8 25.0 1.0
O A:SER12 4.8 23.7 1.0
CG A:PHE192 4.8 72.8 0.5
N A:GLY13 4.8 25.6 1.0
CA A:GLY13 4.9 23.7 1.0
O4B A:NAP360 5.0 37.5 1.0

Phosphorus binding site 2 out of 3 in 1a27

Go back to Phosphorus Binding Sites List in 1a27
Phosphorus binding site 2 out of 3 in the Human 17-Beta-Hydroxysteroid-Dehydrogenase Type 1 C-Terminal Deletion Mutant Complexed with Estradiol and Nadp+


Mono view


Stereo pair view

A full contact list of Phosphorus with other atoms in the P binding site number 2 of Human 17-Beta-Hydroxysteroid-Dehydrogenase Type 1 C-Terminal Deletion Mutant Complexed with Estradiol and Nadp+ within 5.0Å range:
probe atom residue distance (Å) B Occ
A:P360

b:38.8
occ:1.00
PN A:NAP360 0.0 38.8 1.0
O2N A:NAP360 1.5 37.1 1.0
O1N A:NAP360 1.5 39.4 1.0
O5D A:NAP360 1.6 37.5 1.0
O3 A:NAP360 1.6 37.4 1.0
C5D A:NAP360 2.7 37.6 1.0
O A:HOH618 2.9 77.8 1.0
PA A:NAP360 2.9 39.8 1.0
O5B A:NAP360 3.2 39.7 1.0
O2A A:NAP360 3.4 38.5 1.0
OG1 A:THR190 3.4 46.0 1.0
C5B A:NAP360 3.8 38.6 1.0
C4D A:NAP360 3.8 39.1 1.0
O4D A:NAP360 3.8 38.3 1.0
CB A:THR190 3.8 47.7 1.0
O A:HOH525 3.8 28.7 1.0
CG2 A:THR190 3.9 46.8 1.0
CB A:PHE192 4.0 72.2 0.5
N7N A:NAP360 4.1 42.2 1.0
O1A A:NAP360 4.1 38.3 1.0
CG A:PHE192 4.3 72.8 0.5
C2N A:NAP360 4.3 39.5 1.0
CD1 A:PHE192 4.4 73.0 0.5
C3D A:NAP360 4.5 38.3 1.0
N A:ILE14 4.5 22.8 1.0
CG1 A:ILE14 4.5 27.9 1.0
CA A:GLY13 4.7 23.7 1.0
C1D A:NAP360 4.7 38.8 1.0
C2D A:NAP360 4.8 39.2 1.0
CD1 A:ILE14 4.8 29.8 1.0
CA A:PHE192 4.9 71.5 0.5

Phosphorus binding site 3 out of 3 in 1a27

Go back to Phosphorus Binding Sites List in 1a27
Phosphorus binding site 3 out of 3 in the Human 17-Beta-Hydroxysteroid-Dehydrogenase Type 1 C-Terminal Deletion Mutant Complexed with Estradiol and Nadp+


Mono view


Stereo pair view

A full contact list of Phosphorus with other atoms in the P binding site number 3 of Human 17-Beta-Hydroxysteroid-Dehydrogenase Type 1 C-Terminal Deletion Mutant Complexed with Estradiol and Nadp+ within 5.0Å range:
probe atom residue distance (Å) B Occ
A:P360

b:46.9
occ:1.00
P2B A:NAP360 0.0 46.9 1.0
O1X A:NAP360 1.4 47.6 1.0
O2B A:NAP360 1.4 42.5 1.0
O2X A:NAP360 1.4 45.8 1.0
O3X A:NAP360 1.4 47.2 1.0
C2B A:NAP360 2.5 38.6 1.0
C3B A:NAP360 3.5 37.3 1.0
O A:HOH550 3.6 21.9 1.0
C1B A:NAP360 3.7 37.2 1.0
OG A:SER11 3.7 28.0 1.0
O3B A:NAP360 3.8 34.2 1.0
CZ A:ARG37 3.8 52.0 1.0
O A:HOH605 3.8 46.0 1.0
O A:HOH524 3.8 18.8 1.0
NH1 A:ARG37 3.9 54.0 1.0
NH2 A:ARG37 3.9 50.5 1.0
N9A A:NAP360 4.0 36.3 1.0
C8A A:NAP360 4.2 34.6 1.0
NE A:ARG37 4.2 48.6 1.0
O A:HOH603 4.3 50.4 1.0
NZ A:LYS195 4.5 87.3 0.5
CB A:ARG37 4.7 30.5 1.0
CB A:SER11 4.7 22.8 1.0
C4A A:NAP360 4.7 35.6 1.0
C4B A:NAP360 4.8 37.1 1.0
O4B A:NAP360 4.8 37.5 1.0
CD A:ARG37 4.8 41.6 1.0
N7A A:NAP360 4.9 34.2 1.0

Reference:

C.Mazza, C.Mazza, R.Breton, D.Housset, J.-C.Fontecilla-Camps. N/A N/A.
Page generated: Fri Sep 25 12:02:54 2020

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