Phosphorus in PDB 1a26: The Catalytic Fragment of Poly(Adp-Ribose) Polymerase Complexed with Carba-Nad

All present enzymatic activity of The Catalytic Fragment of Poly(Adp-Ribose) Polymerase Complexed with Carba-Nad:
2.4.2.30;

The structure of The Catalytic Fragment of Poly(Adp-Ribose) Polymerase Complexed with Carba-Nad, PDB code: 1a26 was solved by A.Ruf, G.E.Schulz, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	22.60 / 2.25
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	59.040, 64.440, 96.720, 90.00, 90.00, 90.00
R / Rfree (%)	16.8 / 23.6

The binding sites of Phosphorus atom in the The Catalytic Fragment of Poly(Adp-Ribose) Polymerase Complexed with Carba-Nad (pdb code 1a26). This binding sites where shown within 5.0 Angstroms radius around Phosphorus atom.
In total 2 binding sites of Phosphorus where determined in the The Catalytic Fragment of Poly(Adp-Ribose) Polymerase Complexed with Carba-Nad, PDB code: 1a26:
Jump to Phosphorus binding site number: 1; 2;

Phosphorus binding site 1 out of 2 in the The Catalytic Fragment of Poly(Adp-Ribose) Polymerase Complexed with Carba-Nad


Mono view


Stereo pair view

A full contact list of Phosphorus with other atoms in the P binding site number 1 of The Catalytic Fragment of Poly(Adp-Ribose) Polymerase Complexed with Carba-Nad within 5.0Å range: probe atom residue distance (Å) B Occ A:P200 b:76.0 occ:1.00 PA A:CNA200 0.0 76.0 1.0 O2A A:CNA200 1.5 79.2 1.0 O1A A:CNA200 1.5 75.6 1.0 O3 A:CNA200 1.6 78.6 1.0 O5B A:CNA200 1.6 80.2 1.0 C5B A:CNA200 2.7 84.8 1.0 PN A:CNA200 2.9 74.1 1.0 O1N A:CNA200 3.2 76.8 1.0 NZ A:LYS903 3.5 43.9 1.0 N A:LEU985 3.7 43.5 1.0 C4B A:CNA200 3.9 91.6 1.0 O5D A:CNA200 3.9 75.8 1.0 O2N A:CNA200 3.9 73.2 1.0 CB A:LEU985 4.0 46.2 1.0 N A:TYR986 4.1 43.3 1.0 CE A:LYS903 4.1 41.9 1.0 CD2 A:TYR986 4.2 46.0 1.0 CA A:LEU985 4.4 45.0 1.0 CD1 A:LEU985 4.4 47.8 1.0 CD2 A:LEU984 4.4 46.6 1.0 CG A:LEU985 4.5 49.3 1.0 C3B A:CNA200 4.5 94.9 1.0 CA A:LEU984 4.6 47.1 1.0 O A:TYR986 4.7 39.1 1.0 C A:LEU984 4.7 44.2 1.0 CB A:TYR986 4.7 43.6 1.0 CD A:LYS903 4.8 40.3 1.0 CB A:LEU984 4.8 47.4 1.0 O3B A:CNA200 4.8 98.1 1.0 C A:LEU985 4.8 44.9 1.0 CG A:TYR986 4.9 46.4 1.0 CA A:TYR986 4.9 41.4 1.0 CE2 A:TYR986 5.0 51.8 1.0

Phosphorus binding site 2 out of 2 in the The Catalytic Fragment of Poly(Adp-Ribose) Polymerase Complexed with Carba-Nad


Mono view


Stereo pair view

A full contact list of Phosphorus with other atoms in the P binding site number 2 of The Catalytic Fragment of Poly(Adp-Ribose) Polymerase Complexed with Carba-Nad within 5.0Å range: probe atom residue distance (Å) B Occ A:P200 b:74.1 occ:1.00 PN A:CNA200 0.0 74.1 1.0 O2N A:CNA200 1.5 73.2 1.0 O1N A:CNA200 1.5 76.8 1.0 O3 A:CNA200 1.6 78.6 1.0 O5D A:CNA200 1.6 75.8 1.0 PA A:CNA200 2.9 76.0 1.0 O5B A:CNA200 3.4 80.2 1.0 O1A A:CNA200 3.6 75.6 1.0 C5B A:CNA200 3.8 84.8 1.0 O A:HOH19 3.9 37.5 1.0 NE2 A:HIS826 4.1 52.8 1.0 O2A A:CNA200 4.1 79.2 1.0 CD2 A:TYR986 4.3 46.0 1.0 CD1 A:LEU985 4.3 47.8 1.0 CE2 A:TYR986 4.6 51.8 1.0 C4B A:CNA200 4.6 91.6 1.0 CE1 A:HIS826 4.6 54.4 1.0

A.Ruf, V.Rolli, G.De Murcia, G.E.Schulz. The Mechanism of the Elongation and Branching Reaction of Poly(Adp-Ribose) Polymerase As Derived From Crystal Structures and Mutagenesis. J.Mol.Biol. V. 278 57 1998.
ISSN: ISSN 0022-2836
PubMed: 9571033
DOI: 10.1006/JMBI.1998.1673