Phosphorus in PDB 1a1c: C-Src (SH2 Domain) Complexed with Ace-Phosphotyr-Glu-(N-Me(-(CH2)3- Cyclopentyl))

Enzymatic activity of C-Src (SH2 Domain) Complexed with Ace-Phosphotyr-Glu-(N-Me(-(CH2)3- Cyclopentyl))

All present enzymatic activity of C-Src (SH2 Domain) Complexed with Ace-Phosphotyr-Glu-(N-Me(-(CH2)3- Cyclopentyl)):
2.7.1.112;

Protein crystallography data

The structure of C-Src (SH2 Domain) Complexed with Ace-Phosphotyr-Glu-(N-Me(-(CH2)3- Cyclopentyl)), PDB code: 1a1c was solved by L.Shewchuk, S.Jordan, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 6.00 / 2.40
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 51.700, 66.900, 75.600, 90.00, 90.00, 90.00
R / Rfree (%) 18.6 / n/a

Phosphorus Binding Sites:

The binding sites of Phosphorus atom in the C-Src (SH2 Domain) Complexed with Ace-Phosphotyr-Glu-(N-Me(-(CH2)3- Cyclopentyl)) (pdb code 1a1c). This binding sites where shown within 5.0 Angstroms radius around Phosphorus atom.
In total 2 binding sites of Phosphorus where determined in the C-Src (SH2 Domain) Complexed with Ace-Phosphotyr-Glu-(N-Me(-(CH2)3- Cyclopentyl)), PDB code: 1a1c:
Jump to Phosphorus binding site number: 1; 2;

Phosphorus binding site 1 out of 2 in 1a1c

Go back to Phosphorus Binding Sites List in 1a1c
Phosphorus binding site 1 out of 2 in the C-Src (SH2 Domain) Complexed with Ace-Phosphotyr-Glu-(N-Me(-(CH2)3- Cyclopentyl))


Mono view


Stereo pair view

A full contact list of Phosphorus with other atoms in the P binding site number 1 of C-Src (SH2 Domain) Complexed with Ace-Phosphotyr-Glu-(N-Me(-(CH2)3- Cyclopentyl)) within 5.0Å range:
probe atom residue distance (Å) B Occ
C:P101

b:12.1
occ:1.00
P C:PTR101 0.0 12.1 1.0
O1P C:PTR101 1.4 17.0 1.0
O2P C:PTR101 1.5 13.3 1.0
O3P C:PTR101 1.5 14.7 1.0
OH C:PTR101 1.8 9.7 1.0
CZ C:PTR101 2.8 12.7 1.0
HH22 A:ARG178 2.9 0.0 1.0
HH12 A:ARG178 3.0 0.0 1.0
HE A:ARG158 3.0 0.0 1.0
H A:GLU181 3.3 0.0 1.0
HH21 A:ARG158 3.4 0.0 1.0
CE1 C:PTR101 3.5 14.6 1.0
H A:THR182 3.5 0.0 1.0
CE2 C:PTR101 3.7 11.7 1.0
H1 C:HOH501 3.8 0.0 1.0
HG A:SER180 3.8 0.0 1.0
O C:HOH501 3.8 23.9 1.0
NH2 A:ARG178 3.8 12.6 1.0
NH1 A:ARG178 3.9 9.5 1.0
OG A:SER180 3.9 17.7 1.0
NE A:ARG158 4.0 20.7 1.0
HG1 A:THR182 4.1 0.0 1.0
N A:GLU181 4.1 25.6 1.0
CB A:THR182 4.2 25.6 1.0
NH2 A:ARG158 4.3 18.5 1.0
CZ A:ARG178 4.3 15.2 1.0
OG1 A:THR182 4.4 28.2 1.0
CB A:ARG158 4.4 13.3 1.0
N A:THR182 4.4 29.7 1.0
CA A:SER180 4.5 19.2 1.0
HH21 A:ARG178 4.6 0.0 1.0
HH11 A:ARG178 4.7 0.0 1.0
CZ A:ARG158 4.7 15.7 1.0
CD1 C:PTR101 4.7 16.0 1.0
CG A:ARG158 4.8 14.4 1.0
C A:SER180 4.8 23.4 1.0
CB A:SER180 4.8 15.9 1.0
H2 C:HOH501 4.8 0.0 1.0
CD A:ARG158 4.8 16.1 1.0
CD2 C:PTR101 4.9 12.9 1.0
CB A:GLU181 4.9 25.2 1.0
CG A:GLU181 4.9 23.5 1.0
CG2 A:THR182 5.0 31.4 1.0
CA A:GLU181 5.0 27.7 1.0

Phosphorus binding site 2 out of 2 in 1a1c

Go back to Phosphorus Binding Sites List in 1a1c
Phosphorus binding site 2 out of 2 in the C-Src (SH2 Domain) Complexed with Ace-Phosphotyr-Glu-(N-Me(-(CH2)3- Cyclopentyl))


Mono view


Stereo pair view

A full contact list of Phosphorus with other atoms in the P binding site number 2 of C-Src (SH2 Domain) Complexed with Ace-Phosphotyr-Glu-(N-Me(-(CH2)3- Cyclopentyl)) within 5.0Å range:
probe atom residue distance (Å) B Occ
D:P101

b:34.6
occ:1.00
P D:PTR101 0.0 34.6 1.0
O1P D:PTR101 1.5 36.4 1.0
O2P D:PTR101 1.5 32.3 1.0
O3P D:PTR101 1.5 39.4 1.0
OH D:PTR101 1.7 30.0 1.0
CZ D:PTR101 2.6 29.4 1.0
HH12 B:ARG178 2.8 0.0 1.0
HH22 B:ARG178 2.8 0.0 1.0
H B:GLU181 3.1 0.0 1.0
HE B:ARG158 3.4 0.0 1.0
H B:THR182 3.4 0.0 1.0
CE1 D:PTR101 3.4 24.1 1.0
HG1 B:THR182 3.5 0.0 1.0
CE2 D:PTR101 3.5 26.4 1.0
HH21 B:ARG158 3.6 0.0 1.0
NH1 B:ARG178 3.7 16.0 1.0
NH2 B:ARG178 3.7 15.4 1.0
OG B:SER180 3.7 32.1 1.0
OG1 B:THR182 4.0 49.6 1.0
N B:GLU181 4.0 40.8 1.0
CZ B:ARG178 4.2 18.1 1.0
CB B:THR182 4.3 48.1 1.0
HG B:SER180 4.3 0.0 1.0
NE B:ARG158 4.3 39.3 1.0
N B:THR182 4.4 49.1 1.0
CA B:SER180 4.4 32.9 1.0
HH11 B:ARG178 4.5 0.0 1.0
HH21 B:ARG178 4.5 0.0 1.0
NH2 B:ARG158 4.5 47.6 1.0
CB B:ARG158 4.6 24.1 1.0
CB B:GLU181 4.6 47.1 1.0
OE2 B:GLU181 4.6 52.7 1.0
CD1 D:PTR101 4.7 26.7 1.0
C B:SER180 4.7 36.7 1.0
CD2 D:PTR101 4.7 28.7 1.0
CB B:SER180 4.7 28.7 1.0
CG B:GLU181 4.8 51.6 1.0
CA B:GLU181 4.9 45.1 1.0
CZ B:ARG158 5.0 43.4 1.0

Reference:

P.S.Charifson, L.M.Shewchuk, W.Rocque, C.W.Hummel, S.R.Jordan, C.Mohr, G.J.Pacofsky, M.R.Peel, M.Rodriguez, D.D.Sternbach, T.G.Consler. Peptide Ligands of PP60(C-Src) SH2 Domains: A Thermodynamic and Structural Study. Biochemistry V. 36 6283 1997.
ISSN: ISSN 0006-2960
PubMed: 9174343
DOI: 10.1021/BI970019N
Page generated: Fri Sep 25 11:57:25 2020

Last articles

Zn in 7M6U
Zn in 7NNG
Zn in 7NEE
Zn in 7NEU
Zn in 7M3K
Zn in 7KWD
Zn in 7KYH
Zn in 7KNG
Zn in 7KY2
Zn in 7KYF
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy